Studies on the influence of brain and neurons of mutation of synaptic cell adhesion molecule protein, Cadm1 using autism mouse models.
| Project/Area Number |
24500386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Jimbo Eriko 自治医科大学, 医学部, 講師 (20291651)
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| Co-Investigator(Kenkyū-buntansha) |
MOMOI Takashi 東京医科大学, 医学部, 客員教授 (40143507)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シナプス接着分子 / Cadm1 / 変異 / シナプス接着因子 |
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| Outline of Final Research Achievements |
Autism spectrum disorder is the neurodevelopmental disorder, characterized by impaired social interactions, social communication impairments. It seems that a combination of genetic and environmental, factors contribute to the pathogenesis of autism.Most candidate genes for conferring susceptibility to autism are known to play a role in brain development.
We previously found missense mutations, in the gene-encoding CADM1 in patients. In this study, we aimed to make clear the molecular mechanisms of Autism, and focus the Cadm1 gene and do some experiment about the protein-complex included Cadm1 using the mice of Cadm1-KO, Cadm1-KI and Cadm1-GFP-Tg.
As the results, we found that the mutated CADM1 affected the synaptogenesis, the neuronal maturation, the formation of CADM1-molecular complex.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy.2013
Author(s)
Golan N, Kartvelishvily E, Spiegel I, Salomon D, Sabanay H, Rechav K, Vainshtein A, Frechter S, Maik-Rachline G, Eshed-Eisenbach Y, Momoi T, Peles E.
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Journal Title
J Neurosci.
Volume: 33
Issue: 27
Pages: 10950-10961
DOI
Related Report
Peer Reviewed
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