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Mechanism of plastic changes in the nervous system that enable juvenile learning

Research Project

Project/Area Number 24500388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionKitasato University

Principal Investigator

OHKI-HAMAZAKI Hiroko  北里大学, 一般教育部, 教授 (00211483)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords行動生理学 / 刷込み行動 / グルタミン酸受容体 / ニワトリ / 幼若期 / 記憶学習 / 神経可塑性 / 行動神経科学 / NMDA受容体 / NR2B / ヒヨコ / 幼弱期 / visual Wulst / IMM
Outline of Final Research Achievements

Imprinting behavior in birds is a good model for juvenile learning, because its critical period resides in several days after hatching. Major excitatory neural transmitter in the brain is glutamate, and an activation of one of its receptors plays a role in the establishment of imprinting behavior. A neural circuit connecting a brain area similar to the visual cortex and a memory storing region is involved in the imprinting behavior, and cells in this neural circuit express this receptor. Imprint training activates and enhances this receptor expressed in these cells by positive feedback. Consequently, transduction of neural information in this circuit is accelerated and enhanced in a short time. It is suggested that this is a mechanism for various juvenile learning.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 6 results) Remarks (2 results)

  • [Journal Article] Positive feedback of NR2B-containing NMDA receptor activity is the initial step toward visual imprinting: a model for juvenile learning.2015

    • Author(s)
      Nakamori T, Sato K, Kinoshita M, Kanamatsu T, Sakagami H, Tanaka K, Ohki-Hamazaki H.
    • Journal Title

      Journal of Neurochemistory

      Volume: 132 Issue: 1 Pages: 110-123

    • DOI

      10.1111/jnc.12954

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Morphology of the olivocerebellar projection of the chick: An axonal reconstruction study.2013

    • Author(s)
      Sasanuma, K., Ohki-Hamazaki, H. and Sugihara, I.
    • Journal Title

      J. Comp. Neurol.

      Volume: 521 Issue: 14 Pages: 3321-3339

    • DOI

      10.1002/cne.23352

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 正常な性周期の発現には、脳が遺伝的に雌であることが必要である:雌雄のニワトリで脳を入れ替えたキメラの解析から2013

    • Author(s)
      浜崎 浩子、前川文彦
    • Journal Title

      細胞工学

      Volume: 32 Pages: 990-991

    • Related Report
      2013 Research-status Report
  • [Journal Article] Neural basis of imprinting behavior in chicks.2013

    • Author(s)
      Tomoharu Nakamori
    • Journal Title

      Development, Growth & Differentiation

      Volume: 55 Issue: 1 Pages: 198-206

    • DOI

      10.1111/dgd.12028

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras2013

    • Author(s)
      Fumihiko Maekawa
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1372-1372

    • DOI

      10.1038/ncomms2372

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] インプリンティング(刷込み記憶)の神経科学2012

    • Author(s)
      浜崎 浩子
    • Journal Title

      BRAIN and NERVE

      Volume: 64 Pages: 657-664

    • Related Report
      2012 Research-status Report
  • [Journal Article] Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.2012

    • Author(s)
      Keiko Suzuki
    • Journal Title

      Journal of Neurochemistry

      Volume: 123 Issue: 5 Pages: 800-810

    • DOI

      10.1111/jnc.12039

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] インプリンティング(刷込み)行動を司る神経回路とその制御機構を探る2014

    • Author(s)
      浜崎 浩子
    • Organizer
      日本動物学会第85回大会 シンポジウム「動物の心の仕組みを探る~神経回路形成と行動制御を司る分子機構~」
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NR2B-dependent neural plastic changes constitute the initial step of juvenile learning.2014

    • Author(s)
      Tomoharu Nakamori, Katsushige Sato, Masae Kinoshita, Kohichi Tanaka, Hiroko Ohki-Hamazaki.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanism of feeding regulation by glucose in the ventromedial hypothalamic nucleus in chick.

    • Author(s)
      Nakamori, T., Nagashima, R., Ohki-Hamazaki, H. and Sato, K.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳の性と性分化~鳥類キメラを用いた解析

    • Author(s)
      浜崎浩子、前川文彦
    • Organizer
      日本下垂体研究会第28回学術集会
    • Place of Presentation
      花巻温泉ホテル千秋閣(岩手県花巻市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 脳原基移植による鳥類キメラを用いた脳細胞自律的な性分化機構の解析

    • Author(s)
      浜崎浩子
    • Organizer
      新学術領域研究「性差構築の分子基盤」第5回領域会議
    • Place of Presentation
      国民宿舎虹の松原ホテル(佐賀県唐津市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ニワトリの脳キメラにおける性分化

    • Author(s)
      浜崎浩子、前川文彦
    • Organizer
      第38回日本比較内分泌学会大会、第40回日本神経内分泌学会学術集会、合同大会
    • Place of Presentation
      宮崎市民プラザ(宮崎県宮崎市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ニワトリの性分化制御における脳の役割

    • Author(s)
      浜崎浩子、前川文彦
    • Organizer
      第37回日本鳥類内分泌研究会
    • Place of Presentation
      アソシエート(熊本県阿蘇郡)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Visual imprinting in chicks requires activation of highly-expressed NR2B-containing NMDA receptors in the neural circuit of the hyperpallium.

    • Author(s)
      Nakamori, T., Sato, K., kinoshita, M., Tanaka, K. and Ohki-Hamazaki, H.
    • Organizer
      Cold Spring Harbor Laboratory Meeting ‘Avian Model Systems’
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] NR2B activation is the first phase of juvenile learning.

    • Author(s)
      Tomoharu Nakamori
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2012 Research-status Report
  • [Presentation] Imprinting behavior in chicks: an excellent model for the study of juvenile learning and memory.

    • Author(s)
      Hiroko Ohki-Hamazaki
    • Organizer
      Chick 7: Avian Model Systems. 7th International Chick Meeting.
    • Place of Presentation
      名古屋大学野依記念学術交流館(愛知)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Remarks] 北里大学 一般教育部 医療系研究科 浜崎浩子研究グループ

    • URL

      http://www.clas.kitasato-u.ac.jp/bio/personal/hamazaki/index2b.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 北里大学一般教育部医療系研究科浜崎浩子研究グループ

    • URL

      http://www.clas.kitasato-u.ac.jp/bio/personal/hamazaki/index2b.html

    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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