| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
During embryonic development, axonal growth cones are guided along their correct routes toward distant targets by a variety of extracellular attractive and repulsive cues. We previously demonstrated that growth cone repulsion, but not attraction, is driven by asymmetric clathrin-mediated endocytosis across the growth cone. In the present study, we identify a 90 kDa splice variant of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIPKIgamma90) as an endocytosis-adaptor protein that mediates growth cone repulsion.
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