Identification of the endocytosis regulator that determines the polarity of neuronal axon guidance
| Project/Area Number |
24500393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TOJIMA Takuro 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (00373332)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 成長円錐 / 軸索ガイダンス / クラスリン依存性エンドサイトーシス / PIPKIgamma90 / AP2 / カルシウム / エンドサイトーシス / クラスリン |
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| Outline of Final Research Achievements |
During embryonic development, axonal growth cones are guided along their correct routes toward distant targets by a variety of extracellular attractive and repulsive cues. We previously demonstrated that growth cone repulsion, but not attraction, is driven by asymmetric clathrin-mediated endocytosis across the growth cone. In the present study, we identify a 90 kDa splice variant of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIPKIgamma90) as an endocytosis-adaptor protein that mediates growth cone repulsion.
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Report
(4 results)
Research Products
(24 results)
