Mechanisms of neuronal fate determination in the cerebral cortex
| Project/Area Number |
24500394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HANASHIMA Carina 独立行政法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (80469915)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 大脳皮質 / ニューロン / 分化 / 遺伝子発現 / 大脳新皮質 / 発生・分化 / 脳・神経 / 神経科学 / 転写因子 |
|---|
| Outline of Final Research Achievements |
The neocortex is comprised of diverse neurons that are organized into six layers and is the processing center for complex behaviors such as perceptions and voluntary movements. Currently, the mechanisms underlying the specification and assembly of each neuronal component of the neocortex remain largely elusive. To understand the organizing principles of the cerebral cortex, we focused on gene program that operates during neural cell differentiation. We first established a system in which temporal subtypes are labeled in developing mouse neocortex, and performed genome-wide analysis to identify layer-specific expressing genes. We further performed functional analysis, and revealed that these molecules are responsible to establish laminar-specific neuronal distribution and dendrite morphology. These studies demonstrated that neocortical circuit formation requires layer-specific gene program that direct the morphogenesis and assembly of individual neuronal subtype during differentiation.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Robo1 modulates proliferation and neurogenesis in the developing neocortex.2014
Author(s)
Yeh, M.L., Gonda, Y., Mommersteeg, M.T., Barber, M., Ypsilanti, A.R., Hanashima, C., Parnavelas, J.G. ＆ Andrews, W.D.
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Journal Title
Journal of Neuroscience
Volume: 34
Issue: 16
Pages: 5717-5731
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Robo1 modulates proliferation and neurogenesis in the developing neocortex.2014
Author(s)
Yeh, M.L., Gonda, Y., Mommersteeg, M.T., Barber, M., Ypsilanti, A.R., Hanashima, C., Parnavelas, J.G. ＆ Andrews, W.D.
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Journal Title
Journal of Neuroscience
Volume: 印刷中
Related Report
Peer Reviewed
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