| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The neocortex is comprised of diverse neurons that are organized into six layers and is the processing center for complex behaviors such as perceptions and voluntary movements. Currently, the mechanisms underlying the specification and assembly of each neuronal component of the neocortex remain largely elusive. To understand the organizing principles of the cerebral cortex, we focused on gene program that operates during neural cell differentiation. We first established a system in which temporal subtypes are labeled in developing mouse neocortex, and performed genome-wide analysis to identify layer-specific expressing genes. We further performed functional analysis, and revealed that these molecules are responsible to establish laminar-specific neuronal distribution and dendrite morphology. These studies demonstrated that neocortical circuit formation requires layer-specific gene program that direct the morphogenesis and assembly of individual neuronal subtype during differentiation.
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