Analysis of basal ganglia-premotor cortex circuitin voluntary movement using photo stimulation

• Project/Area Number: 24500397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Arimura Nariko 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 病態生化学研究部, 流動研究員 (20420375)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大脳基底核 / 神経回路 / 神経科学

Outline of Final Research Achievements

The BG and premotor cortex (PM) are shown to play a crucial role in associating multiple computational processes essential to behavior, including visual signals with actions in a goal-oriented and adaptive manner. However, it is still unknown that the functional relationship and distinct roles between these two regions. In this project, we focus on the basal ganglia-premotor cortex circuit and the neuronal activity during the voluntaly movement based on the prediction in two regions.

Research Products

• [Journal Article] Involvement of the globus pallidus in behavioral goal determination and action specification. (2013)
  • Author(s): Arimura N, Nakayama Y, Yamagata T, Tanji J, Hoshi E.
  • Journal Title: Journal of Neuroscience Volume: 33 (34) Issue: 34 Pages: 13639-53
  • DOI: 10.1523/jneurosci.1620-13.2013
  • Peer Reviewed
• [Presentation] A down syndrome-associated gene controls neuronal migration in mouse mesencephalon. (2015)
  • Author(s): Nariko Arimura, Kenichi Dewa, Yoneko Hayase, Yuchio Yanagawa, Shin-ichiro Taya, Mikio Hoshino.
  • Organizer: Neuro2015
  • Place of Presentation: Kobe
  • Year and Date: 2015-07-28
• [Presentation] Involvement of frontal cortical areas and basal ganglia in behavior mediated by conditional 'visuo-goal' association (2014)
  • Author(s): Yoshihisa Nakayama, Tomoko Yamagata, Nariko Arimura, Jun Tanji, Eiji Hoshi
  • Organizer: 2014 International symposium
  • Place of Presentation: Ito International Research Center, The University of Tokyo, Tokyo
  • Year and Date: 2014-12-06 – 2014-12-07
• [Presentation] 細胞接着因子の細胞膜での発現・局在制御機構の観察系の開発 (2014)
  • Author(s): 川端 政則, 林 崇, 宮下 聡, 田谷 真一郎, 有村 奈利子, 瀬戸 裕介, 早瀬 ヨネ子, 福田 光則, 星野 幹雄
  • Organizer: 第37回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] The functional involvement of a down syndrome-associated gene in the neuronal migration (2014)
  • Author(s): Nariko Arimura, Yuki Nishihara, Yoneko Hayase, Yuchio Yanagawa, Shin-ichiro Taya, Mikio Hoshino
  • Organizer: Neuro2014
  • Place of Presentation: PACIFICO YOKOHAMA, Yokohama
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Differential involvement of the frontal motor areas of macaques in planning and execution of action based on an abstract behavioral goal. (2012)
  • Author(s): Yoshihisa Nakayama, Tomoko Yamagata, Nariko Arimura, Jun Tanji, and Eiji Hoshi
  • Organizer: The 42nd annual meeting of the Society for Neuroscience
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, Louisiana