| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. We identified the responsible gene for IER, Epi-IER, which is expressed in neurons of various brain regions. A single base mutation in Epi-IER caused abnormal splicing leading to lack of Epi-IER protein in IER. Our gain- and loss-of function experiments in vivo and in vitro showed that Epi-IER is involved in neurite extension and branching. These findings help to understand the pathology of epilepsy caused by a malformed neural network and how Epi-IER functions to prevent such disorder.
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