| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The function of synapses is defined largely by the receptor subunits to be transported, the control mechanism by a membrane transport including endosome and recycling endosome, is largely unknown. We focus on rabaptin-5, an effector protein of Rab5, in glutamate receptor trafficking, and have found as following points. 1) Rabaptin-5 is involved in subunit-specific transport of glutamate receptor, 2) activity-dependent changes in the Rabaptin-5 depending on the neural activity history, 3) contribution to the homeostatic synaptic plasticity. These results indicates that membrane transport route through the recycling from endosomes is critical for synaptic function and plasticity expression.
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