| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Neurons are connected via synapses to form neural circuits. In order to understand how neurons are involved in various brain functions at neural circuit level, it will be useful to analyze the wiring diagram of the brain at synapse level with high-resolution imaging technique which can cover large area. From this point of view, I established the hybrid method of light and electron microscopy, Array Tomography, for the three-dimensional reconstruction of neural tissue and synapse localization. I also established the method to observe synapses by using scanning electron microscopy. By using these technologies, I analyzed the morphology of excitatory synapses at developmental stage of mice.
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