| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Our research group has clarified the essential signaling mechanism of the normal extension of dendrites in the Drosophila model system. We have showed that both seven-transmembrane cadherin molecules Flamingo and intracellular binding molecule Espinas prevented cooperatively the dendrites from crossing with each other. By using RNA interference method and Cas9/CRISPR method, we found that intracellular scaffold protein Neurochondrin, one of the identified group of molecules as Espinas binding factor, displayed a similar crossing defects as that of Espinas mutant.
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