• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular analyses of crossing-proof mechanism of dendrites

Research Project

Project/Area Number 24500410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyoto University

Principal Investigator

USUI Tadao  京都大学, 生命科学研究科, 助教 (10324708)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords樹状突起 / 突起間交差忌避 / 細胞間認識タンパク質 / てんかん / 突起間忌避 / 生得行動 / 神経生理 / 神経発生 / カルシウムシグナル / FRET型プローブ
Outline of Final Research Achievements

Our research group has clarified the essential signaling mechanism of the normal extension of dendrites in the Drosophila model system. We have showed that both seven-transmembrane cadherin molecules Flamingo and intracellular binding molecule Espinas prevented cooperatively the dendrites from crossing with each other. By using RNA interference method and Cas9/CRISPR method, we found that intracellular scaffold protein Neurochondrin, one of the identified group of molecules as Espinas binding factor, displayed a similar crossing defects as that of Espinas mutant.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Invited: 3 results)

  • [Journal Article] An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size.2014

    • Author(s)
      Kohei Shimono, Kazuto Fujishima, Takafumi Nomura, Masayoshi Ohashi, Tadao Usui, Mineko Kengaku, Atsushi Toyoda, and Tadashi Uemura.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 4415-4415

    • DOI

      10.1038/srep04415

    • NAID

      120005399036

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.2013

    • Author(s)
      Yukako Hattori, Tadao Usui, Daisuke Satoh, Sanefumi Moriyama, Kohei Shimono, Takehiko Itoh, Katsuhiko Shirahige, Tadashi Uemura.
    • Journal Title

      Developmental Cell

      Volume: 27(5) Issue: 5 Pages: 530-544

    • DOI

      10.1016/j.devcel.2013.10.024

    • NAID

      120005348995

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 高温感覚器への赤外線レーザー刺激と Ca2+イメージングの同時実施2015

    • Author(s)
      碓井理夫
    • Organizer
      第9回バイオイメージング研究会
    • Place of Presentation
      基礎生物学研究所
    • Year and Date
      2015-01-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 侵害覚ニューロンの刺激受容と情報統合メカニズム2014

    • Author(s)
      碓井理夫
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Single-cell multimodal encoding of noxious thermal and light sensation in Drosophila primary somatosensory neurons2014

    • Author(s)
      碓井理夫
    • Organizer
      第11回日本ショウジョウバエ研究会
    • Place of Presentation
      金沢歌劇座
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single-cell multimodal encoding of noxious thermal and light sensation in Drosophila primary sensory neurons2014

    • Author(s)
      Tadao Usui
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜(日本)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Dendritic processing of noxious thermal stimuli in Drosophila sensory neurons2013

    • Author(s)
      Tadao Usui, Shin-Ichiro Terada, Daisuke Matsubara, and Tadashi Uemura
    • Organizer
      Asia Pacific Drosophila Research Conference
    • Place of Presentation
      ソウル(大韓民国)
    • Related Report
      2013 Research-status Report
  • [Presentation] ショウジョウバエの痛覚受容ニューロンは熱刺激と光刺激とを弁別しそれぞれを独自にコード化する2013

    • Author(s)
      碓井理夫、寺田晋一郎、松原大佑、小野寺孝興、松崎政紀、上村匡
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸(日本)
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi