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Morphological analysis of the nociceptive inputs to orexin-containing neurons in the hypothalamus

Research Project

Project/Area Number 24500412
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionShimane University

Principal Investigator

YASUI Yukihiko  島根大学, 医学部, 教授 (30174501)

Co-Investigator(Kenkyū-buntansha) TSUMORI Toshiko  県立広島大学, 保健福祉学部, 教授 (30217377)
YOKOTA Shigefumi  島根大学, 医学部, 助教 (50294369)
OKA Tatsuro  島根大学, 医学部, 助教 (20508923)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsオレキシン / 視床下部 / 結合腕傍核 / 脊髄後角 / 三叉神経脊髄路核 / 覚醒反応 / オレキシンニューロン / 侵害刺激 / コレラ毒Bサブユニット / フルオロゴールド / ビオチン化デキストランアミン / Fos 蛋白
Outline of Final Research Achievements

In this study, we have analyzed the nociceptive inputs to orexin-containing neurons (ORX neurons) in the hypothalamus. The results were as follows: 1)lateral parabrachial (lPBN) neurons that sent projection fibers to the ORX neurons-containing hypothalamic area were activated by nociceptive inputs; 2) these lPBN neurons received projection fibers from the dorsal horn of the spinal cord as well as from the caudal subnucleus of the spinal trigeminal nucleus (Vsp); 3) lPBN-projecting neurons in the dorsal horn and caudal subnucleus of the Vsp were glutamatergic.
These data suggest that nociceptive inputs activate hypothalamic ORX neurons through the pathways from the dorsal horn and the caudal subnucleus of the Vsp to these neurons via the lPBN, resulting in producing arousal response.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) Book (1 results)

  • [Journal Article] Control pathways from the subcortical limbic structures to the trigeminal motor system in the lower brainstem: a hodological review.2015

    • Author(s)
      Y.Yasui
    • Journal Title

      Neuroscience and Medicine

      Volume: 6 Pages: 24-34

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anatomical and functional pathways of rhythmogenic inspiratory premotor information flow originatingin the pre-Botzinger complex in the rat medulla.2014

    • Author(s)
      N. Koshiya, Y.Oku, S. Yokota, Y. Oyamada, Y. Yasui, Y. Okada
    • Journal Title

      Neuroscience

      Volume: 268 Pages: 194-211

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 扁桃体と顎顔面運動2014

    • Author(s)
      安井幸彦
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 652-655

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Anatomical and functional pathways of rhythmogenic inspiratory premotor information flow originating in the pre-Botzinger complex in the rat めづっぁ2014

    • Author(s)
      N. Koshiya, Y. Oku, S. Yokota, Y. Oyamada, Y. Yasui, Y. Okada
    • Journal Title

      Neuroscience

      Volume: 268 Pages: 194-211

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrapancreatic ganglia neurons receive projection fibers from melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve of the mouse2013

    • Author(s)
      T. Tsumori, T. Oka, S. Yokota, J.-G. Niu, Y. Yasui
    • Journal Title

      Brain Research

      Volume: 1537 Pages: 132-142

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Projections from the anterior basomedial and anterior cortical amygdaloid nuclei to melanin-concentrating hormone-containing neurons in the lateral hypothalamus of the rat2012

    • Author(s)
      Niu JG, Yokota S, Tsumori T, Oka T,Yasui Y
    • Journal Title

      Brain Research

      Volume: 1479 Pages: 31-43

    • DOI

      10.1016/j.brainres.2012.08.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glutamatergic neurons in the lateral periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat2012

    • Author(s)
      Tatsuro Oka
    • Journal Title

      Neuroscience Research

      Volume: 74 Issue: 2 Pages: 106-115

    • DOI

      10.1016/j.neures.2012.08.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 高炭酸ガス負荷によって活性化する結合腕傍核から横隔神経核への連絡路2015

    • Author(s)
      横田茂文、Satvinder Kaur、Veronique G. Vanderhorst、Clifford B. Saper B、岡 達郎、安井幸彦、Nancy L. Chamberlin
    • Organizer
      第120回日本解剖学会総会•全国学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Orexinergic fibers are in contact with Kölliker-Fuse neurons projecting to the ventrolateral medulla and phrenic and hypoglossal nuclei in the rat2014

    • Author(s)
      横田茂文、岡 達郎、浅野裕彦、安井幸彦
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lateral periaqueductal gray neurons innervate cholinergic neurons in the pedunculopontine tegmental nucleus of the rat2014

    • Author(s)
      岡 達郎、横田茂文、浅野裕彦、安井幸彦
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional anatomy of the rhythmogenic inspiratory premotor information pathway from the preBötzinger complex2014

    • Author(s)
      岡田泰昌、越久仁敬、横田茂文、小山田吉孝、安井幸彦、越谷直弘
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Orexinergic inputs to Kölliker-Fuse neurons projecting to the ventrolateral medulla and phrenic and hypoglossal nuclei in the rat.2014

    • Author(s)
      横田茂文、岡 達郎、浅野裕彦、安井幸彦
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      栃木県下野市 自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Lateral periaqueductal gray neurons innervate cholinergic neurons in the pedunculopontine tegmental nucleus of the rat2014

    • Author(s)
      岡 達郎、横田茂文、浅野裕彦、安井幸彦
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      栃木県下野市 自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス舌の味蕾は膝神経節および錐体神経節に存在するメラノコルチン4受容体発現ニューロンの神経終末を受ける2013

    • Author(s)
      津森登志子、岡 達郎、横田茂文、安井幸彦
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市 京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 結合腕傍核へ投射する孤束核ニューロンは高炭酸ガス負荷によって活性化される2013

    • Author(s)
      横田茂文、S. Kaur、V.G.J.M. Vanderhorst、C.B. Saper、安井幸彦、N.L. Chamberlin
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市 京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット中心灰白質外側部から脚橋被蓋核コリン作動性ニューロンへの投射2013

    • Author(s)
      岡 達郎、横田茂文、浅野裕彦、安井幸彦
    • Organizer
      日本解剖学会第68回中国四国支部学術集会
    • Place of Presentation
      米子市 鳥取大学医学部
    • Related Report
      2013 Research-status Report
  • [Presentation] Hypercapnia-activated neurons in the nucleus of the solitary tract project to the parabrachial nucleus in the mouse.2013

    • Author(s)
      横田茂文
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松 (サンポートホール高松・かがわ国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] Pancreatic islets cells receive axon terminals from melanocortin-4 receptor-expressing nodose ganglion cells in the mouse.2013

    • Author(s)
      津森登志子
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松 (サンポートホール高松・かがわ国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] 腹側呼吸性ニューロン群、横隔神経核及び舌下神経核へ投射するマウス結合腕傍核ニューロンは高炭酸負荷によって活性化する.2012

    • Author(s)
      横田茂文
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋 (名古屋国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] メラノコルチン4受容体を発現するマウス迷走神経節状神経性ニューロン由来の軸索終末は膵内分泌細胞とシナプスを形成する2012

    • Author(s)
      津森登志子
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋 (名古屋国際会議場)
    • Related Report
      2012 Research-status Report
  • [Book] 中枢神経系(発生、構造). 塩田浩平編:人体の構造と機能2013

    • Author(s)
      安井幸彦
    • Total Pages
      22
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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