A study for the correlation between Alzheimer's disease and angiotensin converting enzyme in human samples
| Project/Area Number |
24500431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Choju Medical Institute, Fukushimura Hospital. |
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Principal Investigator |
AKATSU Hiroyasu 医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, その他 (00399734)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アンギオテンシン変換酵素 / アルツハイマー病 / アミロイド / 遺伝子多型 |
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| Outline of Final Research Achievements |
We revealed it with the mouse and human that amyloid (Aβ) 1-42 could be converted to Aβ1-40 with angiotensin converting enzyme (ACE). The ACE has genetic I(Isoleucine )/D (Aspartic acid) polymorphism that reported that I type holders have the risk of Alzheimer`s diseasae (AD).
In this ersarch, we analyzed I/D polymorphism with 488 cases. The 165 cases have been diagnosed with AD. The analysis of ACE polymorphism, AD group were that DD type was 25 (15%) / ID 73 (44%) / II 67 (41%) and non AD group was DD 42 (13%) / ID 141 (44%) / II. This results did not have statistical significant with Chi-square test. Even focused on apoE negative group, group, the ratio of I/D polymorphism in 84 AD cases was DD 16 (19%) / ID 31 (37%) / II 37 (44%) and no tendency of statistical significant was observed. Unfortunately, with in this study period, we could not get positive findings including the gene analysis. Brain and blood sampling are in progress, we will continue further research.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease2014
Author(s)
Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
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Journal Title
J. Alzheimers Dis
Volume: 39
Issue: 4
Pages: 861-870
DOI
Related Report
Peer Reviewed
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[Journal Article] SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians2013
Author(s)
Miyashita A, Koike A, Jun G, Kawarabayashi T, Shoji M,Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Ikeuchi T, St. George-Hyslop P,
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Journal Title
PLoS One
Volume: 8
Issue: 4
Pages: e58618-e58618
DOI
Related Report
Peer Reviewed
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[Journal Article] Spliceosome integrity is defective in the motor neuron diseases ALS and SMA2013
Author(s)
Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K
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Journal Title
EMBO Mol Med
Volume: 5
Issue: 2
Pages: 221-234
DOI
Related Report
Peer Reviewed / Open Access
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