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A study for the correlation between Alzheimer's disease and angiotensin converting enzyme in human samples

Research Project

Project/Area Number 24500431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionChoju Medical Institute, Fukushimura Hospital.

Principal Investigator

AKATSU Hiroyasu  医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, その他 (00399734)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアンギオテンシン変換酵素 / アルツハイマー病 / アミロイド / 遺伝子多型
Outline of Final Research Achievements

We revealed it with the mouse and human that amyloid (Aβ) 1-42 could be converted to Aβ1-40 with angiotensin converting enzyme (ACE). The ACE has genetic I(Isoleucine )/D (Aspartic acid) polymorphism that reported that I type holders have the risk of Alzheimer`s diseasae (AD).
In this ersarch, we analyzed I/D polymorphism with 488 cases. The 165 cases have been diagnosed with AD. The analysis of ACE polymorphism, AD group were that DD type was 25 (15%) / ID 73 (44%) / II 67 (41%) and non AD group was DD 42 (13%) / ID 141 (44%) / II. This results did not have statistical significant with Chi-square test. Even focused on apoE negative group, group, the ratio of I/D polymorphism in 84 AD cases was DD 16 (19%) / ID 31 (37%) / II 37 (44%) and no tendency of statistical significant was observed. Unfortunately, with in this study period, we could not get positive findings including the gene analysis. Brain and blood sampling are in progress, we will continue further research.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results,  Open Access: 3 results) Presentation (14 results) Remarks (2 results)

  • [Journal Article] Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.2015

    • Author(s)
      Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I
    • Journal Title

      Neurosci Lett.

      Volume: 5901 Pages: 19-24

    • DOI

      10.1016/j.neulet.2015.02.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis.2015

    • Author(s)
      Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo'oka T.
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci.

      Volume: 974 Pages: 24-34

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of genetic association between TREM2 and late-onset Alzheimer’s disease in a Japanese population2014

    • Author(s)
      Akinori Miyashitaa, Yanan Wen 他
    • Journal Title

      J Alzheimer's Dis.

      Volume: 印刷中 Issue: 4 Pages: 1301-1308

    • DOI

      10.3233/jad-140225

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinction between mild cognitive impairment and Alzhemer’s disease by CSF amyloid beta40 and beta42, and protein-conjugated acrolein.2014

    • Author(s)
      Mizoi, M. et al.
    • Journal Title

      Clin. Chim. Acta

      Volume: 430 Pages: 150-155

    • DOI

      10.1016/j.cca.2014.01.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease2014

    • Author(s)
      Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
    • Journal Title

      J. Alzheimers Dis

      Volume: 39 Issue: 4 Pages: 861-870

    • DOI

      10.3233/jad-131610

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.2014

    • Author(s)
      Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T.
    • Journal Title

      Anal Chem.

      Volume: 86 Issue: 1 Pages: 797-804

    • DOI

      10.1021/ac403315h

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 展望 認知症の分析科学的アプローチ2013

    • Author(s)
      井之上浩一
    • Journal Title

      ぶんせき

      Volume: 3月号 Pages: 132-139

    • Related Report
      2012 Research-status Report
  • [Journal Article] SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians2013

    • Author(s)
      Miyashita A, Koike A, Jun G, Kawarabayashi T, Shoji M,Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Ikeuchi T, St. George-Hyslop P,
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e58618-e58618

    • DOI

      10.1371/journal.pone.0058618

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microsomal prostaglandin E synthase-1 is induced in Alzheimer's disease and its deletion mitigates Alzheimer's disease-like pathology in a mouse model2013

    • Author(s)
      Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M
    • Journal Title

      J. Neurosci. Res

      Volume: 91(7) Issue: 7 Pages: 909-919

    • DOI

      10.1002/jnr.23217

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease2013

    • Author(s)
      Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, et al.
    • Journal Title

      J Alzheimers Dis

      Volume: 35(2) Issue: 2 Pages: 387-94

    • DOI

      10.3233/jad-122395

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spliceosome integrity is defective in the motor neuron diseases ALS and SMA2013

    • Author(s)
      Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K
    • Journal Title

      EMBO Mol Med

      Volume: 5 Issue: 2 Pages: 221-234

    • DOI

      10.1002/emmm.201202303

    • Related Report
      2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transition metal abnormalities in progressive dementias.2012

    • Author(s)
      Akatsu H
    • Journal Title

      Biometals

      Volume: Apr;25(2) Issue: 2 Pages: 337-350

    • DOI

      10.1007/s10534-011-9504-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes.2012

    • Author(s)
      Satoh K
    • Journal Title

      Brain Res

      Volume: Mar 2;1441 Pages: 9-16

    • DOI

      10.1016/j.brainres.2011.12.062

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.2012

    • Author(s)
      Yokota T
    • Journal Title

      FEBS Lett

      Volume: Dec 14;586(24): Issue: 24 Pages: 4357-4361

    • DOI

      10.1016/j.febslet.2012.10.050

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple findings in elderly adults with confirmed Alzheimer's disease.2012

    • Author(s)
      Akatsu H
    • Journal Title

      J Am Geriatr Soc.

      Volume: Nov;60(11) Issue: 11 Pages: 2169-2170

    • DOI

      10.1111/j.1532-5415.2012.04224.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid beta plaques of Alzheimer's disease : Evidence from mouse models and patients2012

    • Author(s)
      Hosono-Fukao, T, et al
    • Journal Title

      Am.J.Pathol

      Volume: 180 Issue: 5 Pages: 2056-2067

    • DOI

      10.1016/j.ajpath.2012.01.015

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 質量分析を基盤とする認知症患者病理資料のノンターゲット多変量解析2014

    • Author(s)
      井之上浩一、赤津裕康、山本誠、土屋浩史、宮崎康人、松川則之、橋詰良夫、道川誠、山本孝之、豊岡利正
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルツハイマー病とアンギオテンシン変換酵素遺伝子多型の関連(連続剖検脳症例を用いて)2014

    • Author(s)
      赤津裕康、山本孝之、大原弘隆
    • Organizer
      第56回日本老年医学会学術集会・総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルツハイマー病とアンギオテンシン変換酵素遺伝子多型の関連(連続病理解剖症例を用いて)2014

    • Author(s)
      赤津裕康、山本孝之、大原弘隆
    • Organizer
      日本老年学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト脳メタボライトプロファイリングによるアルツハイマー病新規低分子バイオ マーカー探索研究2013

    • Author(s)
      筒井 陽仁
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Research-status Report
  • [Presentation] Increased Protein-Conjugated Acrolein and Beta-Amyloid 40/42 Ratio in the Plasma in Patients With Mild Cognitive Impairment and Alzheimer’s Disease2012

    • Author(s)
      Waragai M
    • Organizer
      国際アルツハイマー学会
    • Place of Presentation
      バルセロナ国際会議場(スペイン・バルセロナ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Increase of p3-Alc Peptides in the CSF and Plasma of Sporadic Alzheimer’s Disease Patients.2012

    • Author(s)
      Hata S
    • Organizer
      国際アルツハイマー学会
    • Place of Presentation
      バルセロナ国際会議場(スペイン・バルセロナ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Techniques for Histopathological Verification of Florbetaben PET in a Global Phase III Clinical Trial.2012

    • Author(s)
      Seibyl J
    • Organizer
      国際アルツハイマー学会
    • Place of Presentation
      バルセロナ国際会議場(スペイン・バルセロナ)
    • Related Report
      2012 Research-status Report
  • [Presentation] The Clinicopathological Analysis of Autopsy-Confirmed Alzheimer’s Disease.2012

    • Author(s)
      Akatsu H
    • Organizer
      国際アルツハイマー学会
    • Place of Presentation
      バルセロナ国際会議場(スペイン・バルセロナ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of Aβ Levels in Nasal Smears of Patients With Alzheimer’s Disease.2012

    • Author(s)
      Fukuhara T
    • Organizer
      国際アルツハイマー学会
    • Place of Presentation
      バルセロナ国際会議場(スペイン・バルセロナ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Multicentre Phase III Trial on Florbetaben for Beta-Amyloid Brain PET in Alzheimer’s Disease.2012

    • Author(s)
      Sabbagh M
    • Organizer
      国際アルツハイマー学会
    • Place of Presentation
      バルセロナ国際会議場(スペイン・バルセロナ)
    • Related Report
      2012 Research-status Report
  • [Presentation] 福祉村Brain Bank 年間報告2012

    • Author(s)
      赤津裕康
    • Organizer
      第53回日本神経病理学会総会学術研究会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト鼻粘膜でのAβ解析と臨床補助診断の検討

    • Author(s)
      赤津裕康
    • Organizer
      第2回日本認知症予防学会学術集会
    • Place of Presentation
      北九州国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 臨床的に前頭側頭型認知症(FTD)/筋萎縮性側策硬化症を伴うFTD (ALSD/MND with FTD)が疑われた58歳男性

    • Author(s)
      赤津裕康
    • Organizer
      日本神経病理学会関東地方会
    • Place of Presentation
      順天堂大学(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] 臨床的に前頭側頭型認知症(FTD)/筋萎縮性側策硬化症を伴うFTD (ALSD/MND with FTD)が疑われた58歳男性

    • Author(s)
      赤津裕康
    • Organizer
      名古屋神経病理アカデミー
    • Place of Presentation
      大日本製薬名古屋支社(愛知)
    • Related Report
      2012 Research-status Report
  • [Remarks] 福祉村病院長寿医学研究所/神経病理研究所 ホームページ

    • URL

      http://www.chojuken.net/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 医療法人さわらび会福祉村病院長寿医学研究所

    • URL

      http://www.chojuken.net/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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