| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
To learn whether altered brain γ-secretase activity contributes to the deposition of amyloid β-protein (Aβ) in the sporadic Alzheimer’s disease patients, γ-secretase activity in the brain was assessed using in vitro reconstituted Aβ generation system in the presence of CHAPSO. γ-Secretase activity in the brain was regulated in the developmental stage-dependent manner．The regional distribution and age-dependent alteration of the γ-secretase activity were little correlated with various indexes of Aβ deposition as well as risk factors for AD. Thus, the quantitative alteration of γ-secretase activity during aging may not be involved in the pathological Aβ deposition in the brain. Further analysis regarding the modulation of γ-secretase activity (variability of cleavage sites) in the brain is ongoing.
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