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The effects of endogenous adenosine on hippocampal synaptic plasticity induced by low-frequency stimulayion

Research Project

Project/Area Number 24500434
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionYamagata University

Principal Investigator

FUJII Satoshi  山形大学, 医学部, 教授 (80173384)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Yoshihiko  山形大学, 医学部, 准教授 (10361247)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsadenosine / synaptic plasticity / LTP / LTD / hippocampus / NMDA receptors / adenosine A1 receptors / frequency / depotentiation / NMDA receptor / adenosine A1 receptor / astroglia / interneuron / CA1 / シナプス可塑性 / アデノシン受容体 / 海馬
Outline of Final Research Achievements

We studied the effects of adenosine A1 receptors (ADOA1Rs) on the synaptic plasticity in CA1 neurons. In the presence of 100 nM adenosine, we found that a tonic inhibition of interneurons for CA1 pyramidal neurons was decreased. Both potentiation and depression of the synaptic response were induced in CA1 neurons by systematically varying the frequency of low frequency afferent stimulation (LFS) between 1-10 Hz and the pulse number between 40-1000. A pharmacological study indicated that, despite their opposite effects, both the synaptic depression induced by LFS at 1 Hz and the synaptic potentiation induced by LFS at 10 Hz were triggered by co-activation of NMDARs, mGluRs and ADOA1Rs at CA1 synapses. We suggest that activation of ADOA1Rs in inhibitory interneurons suppresses the tonic inhibition for CA1 pyramidal neurons, facilitates NMDARs activation during LFS and triggers the mechanism for the bidirectional synaptic plasticity induced in CA1 neurons by 1-10 Hz LFS.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Book (1 results)

  • [Journal Article] Extracellular ATP modulates synaptic plasticity induced by activation of metabotropic receptors in the hippocampus.2015

    • Author(s)
      Yamazaki, Y., Fujii, S.
    • Journal Title

      Biomedical Research

      Volume: 36 Pages: 1-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased adenosine levels in mice expressing mutant glial fibrillary acidic protein in astrocytes result in failure of induction of LTP reversal (depotentiation) in hippocampal CA1 neurons.2014

    • Author(s)
      Fujii S, Tanaka KF, Ikenaka K, Yamazaki Y.
    • Journal Title

      Brain Res

      Volume: 1578 Pages: 1-13

    • DOI

      10.1016/j.brainres.2014.07.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of synaptic plasticity by the coactivation of spatially distinct synaptic inputs in rat hippocampal CA1 apical dendrites2013

    • Author(s)
      Masashi Kondo, Tatsuo Kitajima, Satoshi Fujii, Minoru Tsukada, Takeshi Aihara
    • Journal Title

      Brain Research

      Volume: vo1.1526 Pages: 1-14

    • DOI

      10.1016/j.brainres.2013.05.023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased astrocytic ATP release results in enhanced excitability of the hippocampus.2012

    • Author(s)
      Lee HU, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K.
    • Journal Title

      These^† authors contributed equally to this work

      Volume: 61 Issue: 2 Pages: 210-224

    • DOI

      10.1002/glia.22427

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of inositol 1, 4, 5-trisphosphate receptors during preconditioning low-frequency stimulation leads to reversal of long-term potentiation in hippocampal CA1 neurons2012

    • Author(s)
      Yamazaki Y
    • Journal Title

      Neuroscience

      Volume: 207 Pages: 1-11

    • DOI

      10.1016/j.neuroscience.2012.01.045

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of preconditioning low-frequency stimulation on subsequent induction of long-term potentiation by high frequency stimulation in hippocampal CA3 neurons2012

    • Author(s)
      Yamazaki Y, Fujii S, Goto J, Sugihara T, Sugita M, Fujiwara H, Kaneko K, Aihara T, Mikoshiba K
    • Journal Title

      Brain Research

      Volume: Vol.1449 Pages: 15-23

    • DOI

      10.1016/j.brainres.2012.02.025

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prior synaptic inputs are engraved on the following synaptic plasticity with Inositol 1,4,5-trisphosphate receptor activation in hippocampal neurons2012

    • Author(s)
      Goto J
    • Journal Title

      Messenger

      Volume: 1(2) Issue: 2 Pages: 121-132

    • DOI

      10.1166/msr.2012.1013

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices2012

    • Author(s)
      Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
    • Journal Title

      Histochem CellBiol

      Volume: 137 Issue: 4 Pages: 499-511

    • DOI

      10.1007/s00418-011-0907-y

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Book] Metabotropic glutamate receptors2013

    • Author(s)
      Jun-ichi Goto, Satoshi Fujii, Katsuhiko Mikoshiba
    • Total Pages
      238
    • Publisher
      Nova press
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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