The analysis of brain damage by dysfunction of the endoplasmic reticulum signaling

Research Project

Project/Area Number	24500440
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurochemistry/Neuropharmacology
Research Institution	Yasuda Women's University
Principal Investigator	KONDO Shinichi 安田女子大学, 薬学部, 准教授 (20404395)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	細胞生物学 / 神経科学 / 細胞内ストレス応答 / 国際情報交換
Outline of Final Research Achievements	To elucidate the role of endoplasmic reticulum stress signaling in brain development, we examined the brain of PERK-deficient mice. We showed that the size of whole brain and olfactory bulb were smaller in PERK-deficient mice. In addition, the endoplasmic reticulum stress occurs in mouse subplate neurons at developmental stage. These results suggest that ER stress response have the important role in brain development.

Report

(4 results)