Neuroprotection via lipoprotein receptors against optic neuropathy
| Project/Area Number |
24500441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo University of Pharmacy and Life Science (2013-2014)
Kumamoto University (2012) |
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Principal Investigator |
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| Research Collaborator |
VANCE Jean E. アルバータ大学, 医学部, 教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リポ蛋白 / 緑内障 / グルタミン酸 / 神経科学 / 脂質 / リポタンパク / 神経保護 |
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| Outline of Final Research Achievements |
The leading cause of blindness in Japan is glaucoma, which is one of neurodegenerative disorders. We have previously demonstrated that apolipoprotein E-containing lipoproteins strongly protect primary cultured retinal ganglion cells from trophic factors-withdrawal-induced neurodegeneration. In this study, we showed a neuroprotective mechanism of apolipoprotein E-containing lipoproteins via the lipoprotein receptor against glutamate-induced neurotoxicity. We believe that the results of this study provide a novel therapeutic approach for glaucoma.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Enhancement of FGF-1 release along with cytosolic proteins from rat astrocytes by hydrogen peroxide.2013
Author(s)
Ito, J., Nagayasu, Y., Hoshikawa, M., Kato, K.H., Miura, Y., Asai, K., Hayashi, H., Yokoyama, S., and Michikawa, M
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Journal Title
Brain Res
Volume: 1522
Pages: 12-21
Related Report
Peer Reviewed
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