The role of the trafficking of PlexinA4-containing vesicles in dendritic development
Project/Area Number |
24500444
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Yokohama City University |
Principal Investigator |
YAMASHITA Naoya 横浜市立大学, 医学(系)研究科(研究院), 客員講師 (40508793)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | セマフォリン / プレキシン / グルタミン酸受容体 / 樹状突起成熟 |
Outline of Final Research Achievements |
Neurons are highly polarized cells with axon, dendrites, and cell body. These subcellular compartments need to communicate with each other. For example, signals received in distal axon travel long distances to reach the cell body and/or dendrites. In present study, I identified that the signal elicited by semaphorin3A (Sema3A), a repulsive axon guidance molecule, enhances dendritic transport of glutamate receptors in hippocampal neurons through PlexinA4, one of the receptor component of Sema3A. I further found that this novel Sema3A action that enhances glutamate receptor trafficking is also required for dendritic morphology and maturation. My findings therefore play an essential role in proper neuronal development.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice.2015
Author(s)
Yamashita N, Jitsuki-Takahashi A, Ogawara M, Ohkubo W, Araki T, Hotta C, Tamura T, Hashimoto SI, Yabuki T, Tsuji T, Sasakura Y, Okumura H, Takaiwa A, Koyama C, Murakami K, Goshima Y.
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Journal Title
International Immunology
Volume: in press
Pages: 1-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Amyloid-β 25-35 induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2.2013
Author(s)
Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y.
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Journal Title
Neuroscience Research
Volume: 77
Pages: 180-185
DOI
Related Report
Peer Reviewed
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[Journal Article] Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice.2013
Author(s)
Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda MC, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R.
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Journal Title
Developmental Neurobiology
Volume: 73
Pages: 502-517
DOI
Related Report
Peer Reviewed
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