Redox-dependent regulation of an endoplasmic reticulum resident protein in neural function
| Project/Area Number | 24500451 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HISATSUNE Chihiro 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (10321803)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed(Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost : ¥4,000,000、Indirect Cost : ¥1,200,000)
Fiscal Year 2014 : ¥1,040,000 (Direct Cost : ¥800,000、Indirect Cost : ¥240,000)
Fiscal Year 2013 : ¥2,080,000 (Direct Cost : ¥1,600,000、Indirect Cost : ¥480,000)
Fiscal Year 2012 : ¥2,080,000 (Direct Cost : ¥1,600,000、Indirect Cost : ¥480,000)
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| Keywords | 酸化還元 / 小胞体 |
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| Outline of Final Research Achievements |
In this study, we found that ERp44, a factor involved in disulfide bond formation in the endoplasmic reticulum (ER), regulates angiotensin II. In mice, genetic loss of ERp44 destabilizes angiotensin II and causes hypotension. We found that ERp44 forms a mixed disulfide bond with ERAP1, an aminopeptidase that cleaves angiotensin II. ERp44 controls release of ERAP1 in a redox-dependent manner to control blood pressure. Additionally, we found that systemic inflammation triggers ERAP1 retention in the ER to inhibit hypotension. These results suggest that ERp44 redox-dependently regulates the intra- or extra-cellular localization of ERAP1, which contributes the control of serum angiotensin II level and blood pressure.
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Report
(4results)
Research Products
(16results)
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[Journal Article] Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.2014
Author(s)
Klar J, Hisatsune C, Baig SM, Tariq M, Johansson AC, Rasool M, Malik NA, Ameur A, Sugiura K, Feuk L, Mikoshiba K, Dahl N.
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Journal Title
J Clin Invest.
Volume : 124
Pages : 4773-80
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.2014
Author(s)
Hamada K, Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Hisatsune C, Nakamura T, Mikoshiba K.
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Journal Title
Proc Natl Acad Sci U S A.
Volume : 111
Pages : 3966-3975
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.2014
Author(s)
Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Ebisui E, Ogawa N, Matsui M, Takeuchi T, Mikoshiba K, Tsubota K.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice.2013
Author(s)
Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui E, Ohshima T, Yamada M, Hensch TK, Hattori M, Mikoshiba K.
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Journal Title
Front Neural Circuits.
Volume : ７
Pages : 156-156
DOI
Related Report
Peer Reviewed
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