Development of behavioral paradigms to evaluate cerebellar cognitive functions

• Project/Area Number: 24500455
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Hokkaido University
• Principal Investigator: KURKIN SERGEY 北海道大学, 医学(系)研究科(研究院), 助教 (00344466)
• Co-Investigator(Kenkyū-buntansha): TANAKA Masaki 北海道大学, 大学院医学研究科, 教授 (90301887)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Hidenao 北海道大学, 大学院医学研究科, 教授 (80281806) ; YABE Ichiro 北海道大学, 大学院医学研究科, 准教授 (60372273)
• Research Collaborator: UEMATSU Akiko ; MATSUYAMA Kei ; YOSHIDA Atsushi ; ITOH Sayaka ; MATSUSHIMA Ayano
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 脊髄小脳変性症 / 高次機能 / 脳画像 / 課題開発 / 半月小葉 / マカクサル / 予測制御 / 小脳 / 高次脳機能 / 霊長類 / 心理物理検査

Outline of Final Research Achievements

The cerebellum is interconnected with the association areas in the frontal and parietal cortices, and therefore is thought to play roles in non-motor cognitive functions such as time perception and prediction. We devised a variety of psychophysical tests to evaluate cerebellar cognitive functions and examined the performance of patients with spinocerebellar degeneration (type 6). We found that some behavioral parameters differed significantly between patents and matched controls, and correlated with the volume of lateral cerebellum (Crus I and II). Furthermore, we trained monkeys in similar behavioral paradigms for future physiological studies.

Research Products

• [Journal Article] No-go neurons in the cerebellar oculomotor vermis and caudal fastigial nuclei: planning tracking eye movements. (2014)
  • Author(s): Kurkin S, Akao T, Fukushima J, Shichinohe N, Kaneko CR, Belton T, Fukushima K.
  • Journal Title: Exp Brain Res. Volume: 232 Issue: 1 Pages: 191-210
  • DOI: 10.1007/s00221-013-3731-x
  • Peer Reviewed
• [Journal Article] Different neuronal computations of spatial working memory for multiple locations within versus across visual hemifields. (2014)
  • Author(s): Matsushima, A. & Tanaka, M.
  • Journal Title: J. Neurosci. Volume: 34 Issue: 16 Pages: 5621-5626
  • DOI: 10.1523/jneurosci.0295-14.2014
  • NAID: 120005476076
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Temporally specific sensory signals for the detection of stimulus omission in the primate deep cerebellar nuclei. (2013)
  • Author(s): Ohmae, S., Uematsu, A. & Tanaka, M.
  • Journal Title: J. Neurosci. Volume: 33 Issue: 39 Pages: 15432-15441
  • DOI: 10.1523/jneurosci.1698-13.2013
  • NAID: 120005434489
  • Peer Reviewed
• [Journal Article] 時間の測り方 ―脳による時間の符号化 (2013)
  • Author(s): 田中真樹、國松 淳、大前彰吾
  • Journal Title: 脳と神経（Brain and Nerve） Volume: 65 Pages: 941-948
• [Presentation] Spatiotemporal adaptation of predictive saccades in monkeys. (2015)
  • Author(s): 伊藤健史、田中真樹
  • Organizer: 第92回日本生理学会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-21
• [Presentation] 大脳小脳連関と高次機能 (2015)
  • Author(s): 田中真樹
  • Organizer: 平成26年度京大霊長研共同利用研究会
  • Place of Presentation: 京都大学霊長類研究所（犬山市）
  • Year and Date: 2015-03-13
  • Invited
• [Presentation] Contribution of the cerebellar dentate nucleus to the generation of anti-saccades. (2014)
  • Author(s): Kunimatsu J., Suzuki T & Tanaka M.
  • Organizer: Society for Neuroscience, 2014
  • Place of Presentation: ワシントンコンベンションセンター（米国,Washington DC）
  • Year and Date: 2014-11-15
• [Presentation] Anti-saccade signals in the primate cerebellar dentate nucleus. (2014)
  • Author(s): Kunimatsu J., Suzuki T & Tanaka M.
  • Organizer: 2014年日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-11
• [Presentation] Contribution of the cerebellum to perceptual prediction. (知覚的予測における小脳の役割)
  • Author(s): Matsushima, A., Itoh, S., Yoshida, A., Kurkin, S., Yabe, I., Sasaki, H., Tanaka, M.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都国際会館（京都市）
• [Book] 「高次脳機能と小脳」In: Annual Review神経2015 (2015)
  • Author(s): 植松明子、田中真樹
  • Total Pages: 299
  • Publisher: 中外医学社