The association between non-motor symptom and visual hallucination in Parkinson disease
| Project/Area Number |
24500458
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Nagoya University |
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Principal Investigator |
HIRAYAMA Masaaki 名古屋大学, 医学(系)研究科(研究院), 准教授 (30283435)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hirohisa 名古屋大学, 医学部神経内科, 講師 (10378177)
NAKAMURA Tomohiko 名古屋大学, 医学部附属病院, 助教 (00437039)
SOBUE Gen 名古屋大学, 医学部神経内科, 教授 (20148315)
寳珠山 稔 名古屋大学, 脳とこころの研究センター, 教授 (30270482)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 幻覚 / パーキンソン病 / 脳磁図 / 網膜 / 非運動症状 / 視覚感覚野 / 視覚誘発脳磁場 / 加齢 / 反回抑制 / 一次視覚野 / 一次感覚野 / 認知症状 / 痛み関連電位 / 前頭葉機能 / 認知機能 |
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| Outline of Final Research Achievements |
We tried to detect the changes of aging and Parkinson’s disease (PD) in the visual evoked brain response to the primary visual cortex.We measured visual evoked magnetic field (VEF) using MEG. Checker pattern reversal (CPR) and monotonous grating pattern (MGP) stimulation were used.Cognitive function test, the smell test and UPDRS were evaluated in the PD. In CPR stimulus, the latency of 2M and 3M in the elderly had significantly delayed than the younger. The current of 1M, 2M and 3M were significantly greater and the latency of 1M was delayed markedly in the PD, which compared to the elderly. In the PD, 1M latency correlated with UPDRS-1, 3 in both stimuli, and it also correlated with the smell test in CPR stimulus. Diffusion tensor imaging was significantly different between younger and elderly, but no difference was found between PD and elderly. It was suggested that conduction delay corresponding to the checker stimulus occurred in peripheral than the primary visual cortex.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone.2014
Author(s)
Inaba H, Takeshita K, Uchida Y, Hayashi M, Okumura T, Hirashiki A, Yoshikawa D, Ishii H, Yamamoto K, Nakayama T, Hirayama M, Matsumoto H, Matsushita T, Murohara T
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Journal Title
PLOS one
Volume: 9(1)
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.2014
Author(s)
Suga N, Katsuno M, Koike H, Banno H, Suzuki K, Hashizume A, Mano T, Iijima M, Kawagashira Y, Hirayama M, Nakamura T, Watanabe H, Tanaka F, Sobue G
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Journal Title
Neuropathol Appl Neurobiol.
Volume: 40
Issue: 5
Pages: 628-639
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination2013
Author(s)
Watanabe, H. Senda, J. Kato, S. Ito, M. Atsuta, N. Hara, K. Tsuboi, T. Katsuno, M. Nakamura, T. Hirayama, M. Adachi, H. Naganawa, S. Sobue, G.
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Journal Title
Mov Disord
Volume: 28
Issue: 12
Pages: 1732-6
DOI
Related Report
Peer Reviewed
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