A quantitative analysis of the structure and the receptive field properties of the early visual system

• Project/Area Number: 24500460
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Osaka University
• Principal Investigator: SATO HIROMICHI 大阪大学, 医学(系)研究科(研究院), 教授 (50154092)
• Co-Investigator(Renkei-kenkyūsha): SAWAI Hjime. 大阪大学, 大学院医学系研究科, 准教授 (20202103)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 初期視覚系 / 刺激文脈依存的反応修飾 / 網膜神経節細胞 / 外側膝状体 / 一次視覚野 / 古典的受容野 / 受容野周囲抑制 / 刺激特徴選択性 / 視覚系 / 受容野 / 文脈依存的反応修飾 / ネコ / 活動相互相関解析 / 刺激方位 / 空間周波数

Outline of Final Research Achievements

The response magnitudes of neurons in the early visual system, i.e., retina-LGN-V1, is modulated according to the figural-properties of visual stimuli within and outside the receptive field (contextual modulation). To clarify the circuit mechanism of the contextual modulation, I conducted electrophysiological analysis using anesthetized cats. The results are summarized as follows; 1)The contextual modulation started from the retina and became stronger in the further stages. 2) In the neural circuit showing a functional connection, exhibiting the firing correlation, neurons in the different processing stages shared similar stimulus-tuning properties for the modulation. And, 3) The results so far suggested both bottom-up and top-down mechanisms.

Research Products

• [Journal Article] Spatiotemporal characteristics of surround suppression in the primary visual cortex and the lateral genicualte nucleus of cat. (2014)
  • Author(s): Shimegi, S., Ishikawa, A., Kida, H., Sakamoto, H., Hara, S.-I. and Sato, H.
  • Journal Title: Journal of Neurophysiology Volume: 112 Pages: 603-619
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relative spatial frequency tuning of human perception and its contrast dependency. (2014)
  • Author(s): Naito, T., Kasamatsu, T. and Sato, H.
  • Journal Title: Journal of Vision Volume: 14 Issue: 13 Pages: 23-23
  • DOI: 10.1167/14.13.23
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Spike synchronization in cat primary visual cortex depends on similarity of surround suppression magnitude. (2014)
  • Author(s): Naito, T., Kasamatsu, T. and Sato, H.
  • Journal Title: European Journal of Neuroscience Volume: 40 Pages: 1-10
  • Peer Reviewed
• [Journal Article] GABAergic inhibition in shaping the spatial frequency tuning of neurons and its contrast dependency in the dorsal lateral geniculate nucleus of cat. (2013)
  • Author(s): Kimura Akihiro
  • Journal Title: European Journal of Neuroscience Volume: 37 Issue: 8 Pages: 1270-1283
  • DOI: 10.1111/ejn.12149
  • Peer Reviewed
• [Journal Article] Cholinergic modulation of response gain in the rat primary visual cortex (2013)
  • Author(s): Soma S, Shimegi S, Suematsu N, Sato H
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 1-7
  • DOI: 10.1038/srep01138
  • Peer Reviewed
• [Journal Article] Modulation-specific and laminar-dependent effects of acetylcholine on visual responses in the rat primary visual cortex. (2013)
  • Author(s): Shogo Soma, Satoshi Shimegi, Naofumi Suematsu, Hiroshi Tamura, and Hiromichi Sato.
  • Journal Title: PLoS ONE Volume: 8 Issue: 7 Pages: e68430-e68430
  • DOI: 10.1371/journal.pone.0068430
  • Peer Reviewed
• [Journal Article] Effects of stimulus spatial frequency, size, and luminance contrast on orientation tuning of neurons in the dorsal lateral geniculate nucleus of cat. (2013)
  • Author(s): Naito, T., Okamoto, M., Sadakane, O., Shimegi, S., Osaki, H., Hara, S. I., Kimura, A., Ishikawa, A., Suematsu, N., & Sato, H.
  • Journal Title: Neuroscience Research Volume: 77 Issue: 3 Pages: 143-154
  • DOI: 10.1016/j.neures.2013.08.009
  • Peer Reviewed
• [Journal Article] Cholinergic modulation of response gain in the primary visual cortex of the macaque (2012)
  • Author(s): Soma, S., Shimegi, S., Osaki, H. and Sato, H
  • Journal Title: J. Neurophysiol Volume: 107 Issue: 1 Pages: 283-291
  • DOI: 10.1152/jn.00330.2011
  • Peer Reviewed
• [Journal Article] Relationship between orientation sensitivity and spatiotemporal receptive field structures of neurons in the cat lateral geniculate nucleus. (2012)
  • Author(s): Suematsu N, Naito T, Sato H.
  • Journal Title: Neural Networks Volume: 35 Pages: 10-20
  • DOI: 10.1016/j.neunet.2012.06.008
  • Peer Reviewed
• [Presentation] The similarity of receptive field properties in connections between the retina, the lateral geniculate nucleus and the primary visual cortex of the cat. (2015)
  • Author(s): Suematsu, N., Naito, T., Miyoshi, T., Sawai, H. and Sato, H.
  • Organizer: 第120回日本解剖学会第92回日本生理学会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-03-23
• [Presentation] The Similarity of Receptive Field Properties in Connections between the Lateral Geniculate Nucleus and the Primary Visual Cortex of the Cat. (2014)
  • Author(s): Naofumi Suematsu1, Tomoyuki Naito1, Tomomitsu Miyoshi2, Hajime Sawai2, Hiromichi Sato
  • Organizer: 第37回日本神経科学大会（Neuro2014）
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Underlying mechanisms of temporal shrinkage of receptive field of relay cells in the dorsal geniculate nucleus of the cat. (ネコ外側膝状体中継細胞における時間経過に伴う受容野縮小のメカニズム) (2014)
  • Author(s): Kimura, A., Shimegi, S. and Sato, H.
  • Organizer: 第37回日本神経科学大会（Neuro2014）
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] The temporal dynamics and underlying mechanisms of orientation tuning of neurons in the cat lateral geniculate nucleus. (2014)
  • Author(s): Naito,T., Suematsu, N., Miyoshi, T., Sawai, H. and Sato, H.
  • Organizer: 脳と心のノメカニズム、第14回冬のワークショップ
  • Place of Presentation: 北海道、留寿都
• [Presentation] Mechanism of receptive field generation in early visual pathway: simultaneous recording of retinal ganglion cells and lateral geniculate cells. (2014)
  • Author(s): Miyoshi, T., Suematsu, N., Sawai, H., Naito, T. and Sato, H.
  • Organizer: 第91回日本生理学会
  • Place of Presentation: 鹿児島市
• [Presentation] Connection principles underlying the spatio-temporal receptive field structure of cat retinogeniculate pathway. (2013)
  • Author(s): Sato,H., Suematsu, N., Naito, T., Miyoshi, T. and Sawai, H.
  • Organizer: IUPS
  • Place of Presentation: Birmingham, UK
• [Presentation] Spatiotemporal Receptive Field Structures in the Retinogeniculate Connections of Cat (2013)
  • Author(s): Suematsu, N.,Naito, T. Miyoshi, T., Sawai, H. an Sato, H.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Relationship between the color coordinate of artworks in the HSV space and the subjective evaluation (2013)
  • Author(s): Sato, H. and Naito, T.
  • Organizer: Beauty and Value
  • Place of Presentation: Berlin, Germany
• [Presentation] The neural representation of brightness and its temporal dynamics in the cat primary visual cortex (2013)
  • Author(s): himegi, Soma, S., Suematsu, N., Kimura, A., Sato, A., Yoshioka, D. and Sato, H.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Functional role of acetylcholine in the primary visual cortex of rat (2013)
  • Author(s): Soma, S., Shimegi, S., Suematsu, N., Mizuyama, R. and Sato, H.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Neurons in the cat primary visual cortex is selective for skewed-statistics-related surface properties of visual images. (2013)
  • Author(s): Naito, T., Suematsu, N., Miyoshi, T., Sawai, H. and Sato, H.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Functional role of cholinergic system in the rat primary visual cortex (2013)
  • Author(s): Shogo Soma, Satoshi Shimegi, Naofumi Suematsu, and Hiromichi Sato
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] ネコ網膜神経節細胞及び外側膝状体における輝度コントラスト不変的刺激方位チューニング（Contrast-invariant orientation tuning of retinal ganglion cells and neurons in the lateral geniculate nucleus of cat) (2012)
  • Author(s): 内藤智之、末松尚史、三好智満、澤井元、佐藤宏道
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] ネコ外側膝状体ニューロンの楕円形受容野を形成する網膜－外側膝状体の機能的結合（Retinogeniculate connection underlying the elliptical receptive fields of the cat lateral geniculate nucleus) (2012)
  • Author(s): 末松尚史、内藤智之、三好智満、澤井元、佐藤宏道
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] ラット一次視覚野におけるコリン作動性視覚応答調節（Modulation of visual responses by acethylcholine in the rat primary visual cortex) (2012)
  • Author(s): 相馬祥吾、七五三木聡、末松尚史、佐藤宏道
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] Retinogeniculate connection and elliptical receptive fields of neurons in the cat lateral geniculate nucleus. (2012)
  • Author(s): 末松尚史
  • Organizer: 包括脳夏のワークショップ
  • Place of Presentation: 仙台
• [Presentation] ネコ外側膝状体ニューロンの楕円形受容野と網膜－外側膝状体間の機能的結合の関係
  • Author(s): 末松尚史、内藤智之、三好智満、澤井元、佐藤宏道
  • Organizer: 第105回近畿生理談話会
  • Place of Presentation: 関西医科大学（守口市）
• [Presentation] ネコ網膜神経節細胞と外側膝状体ニューロンにおける刺激コントラストに依存しない方位選択性の形成メカニズム
  • Author(s): 内藤智之、末松尚史、三好智満、澤井元、佐藤宏道
  • Organizer: 第105回近畿生理談話会
  • Place of Presentation: 関西医科大学（守口市）
• [Presentation] The neural representation of lightness in the cat primary visual cortex. (ネコ一次視覚野における明るさを表現するニューロン応答)
  • Author(s): Sato, Akinori; Yoshioka, Daiske; Soma, Shogo; Suematsu, Naofumi; Shimegi, Satoshi; Sato, Hiromichi
  • Organizer: 第90回日本生理学大会
  • Place of Presentation: 東京
• [Presentation] Response-based suppression of the cat primary visual cortex.
  • Author(s): Yoshioka, Daiske;_ Sato, Akinori; Soma, Shogo; Suematsu, Naofumi; Shimegi, Satoshi; Sato, Hiromichi
  • Organizer: 第90回日本生理学大会
  • Place of Presentation: 東京
• [Presentation] A new efficient measurement of contrast sensitivity function in the behaving Long-Evans rat.
  • Author(s): Soma, Shogo; Suematsu, Naofimi; Shimegi, Satoshi; Sato, Hiromichi.
  • Organizer: 第90回日本生理学大会
  • Place of Presentation: 東京
• [Remarks] 大阪大学大学院医学系研究科認知行動科学教室
  • URL: http://www.vision.hss.osaka-u.ac.jp/
• [Remarks] 佐藤宏道研究室 最近の業績
  • URL: http://www.vision.hss.osaka-u.ac.jp/index.files/current_papers.html