Modulation of striatal synaptic tramsmission by cell surface and intracellular functionbal molecules
| Project/Area Number |
24500464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ドーパミン / ムスカリン / セロトニン / 線条体 / 海馬 / 前脳基底核 / パッチクランプ / シナプス伝達 / 5-HT1B受容体 / カリウムイオン / スライス / ノックアウトマウス / 大脳基底核 / シナプス / 行動 / アセチルコリン性ニューロン / D2型受容体 / ムスカリン受容体 / ドーパミン受容体 / プリン受容体 / カルシウムチャネル / 細胞内受容体 / D2受容体 / 刺激頻度依存性 |
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| Outline of Final Research Achievements |
Central synaptic transmission is regulated by various molecules on the surface of cell membranes as well as in the cytosoles. In the present grant project, I have clarified 1) modulatory roles of intracellular muscarinic receptor M1 subtype in the regulation of long term potentiation in the hippocampal excitatory synaptic transmission, 2) functions of physiologically released dopamine in the inhibitory synapse and neuronal activities in the striatum, 3) presynaptic inhibition of inhibitory synaptic transmission in the basal forebrain by serotonin 5-HT1B receptors. I'm also analyzing the functions of intracellular transcription factors in the excitatory anｄ inhibitory transmission in the striatum.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus.2013
Author(s)
Anisuzzaman AS1, Uwada J, Masuoka T, Yoshiki H, Nishio M, Ikegaya Y, Takahashi N, Matsuki N, Fujibayashi Y, Yonekura Y, Momiyama T, Muramatsu I.
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Journal Title
Journal of Neurochemistry
Volume: 126
Issue: 3
Pages: 360-371
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus2013
Author(s)
Anisuzzaman ASM, Uwada J, Matsuoka T, Yoshiki H, Nishio M, Ikmegaya Y, Takahashi N, Matsuki N, Fujibayashi Y, Yonekura Y, Momiyama, T & Muramatsu I
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Journal Title
Journal of Neurochemistry
Volume: in press
Related Report
Peer Reviewed
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