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Investigation of microglial activation through noradrenaline in the process of neurodegenerative disease

Research Project

Project/Area Number 24500465
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionNippon Medical School

Principal Investigator

SUGAMA Shuei  日本医科大学, 医学部, 講師 (70302461)

Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Makoto   (50189502)
TAKENOUCHI Takato   (20292518)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsミクログリア / ストレス / ノルアドレナリン / 青斑核 / アドレナリン受容体 / 脳内免疫 / 慢性ストレス / 黒質 / ドーパミン / ニトロタイロシン / 酸化ストレス / 神経免疫 / 神経科学 / 海馬 / 視床下部 / 副腎ステロイド / 脳内炎症
Outline of Final Research Achievements

We have demonstrated the first evidence that acute stress could induce morphological microglial activation in the brain. The goal of this study was to investigate the mechanism how the microglial activation is triggeredd by exposures to acute stress. We found that Dopamine beta Hydroxylase (DBH), an enzyme required for the synthesis of noradrenaline in the brain, is significantly elevated in the hippocampus, thalamus, and hypothalamus in response to acute stress. In addition, we found that DBH immunoreactive fibers surround microglial cells. Those microglial cells were found to be positive to beta 1 and beta 2 Adrenergic Receptor (AR). We suggest that microglia may be modulated through noradrenaline during the time of acute stress.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Disease-Modifying Effect of Adiponectin in Model of a-Synucleinopathies2014

    • Author(s)
      Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M
    • Journal Title

      Ann Clin Transl Neurol

      Volume: 1 Pages: 479-489

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Corticosteroids limit microglial activation occurring during acute stress2012

    • Author(s)
      Sugama S, Takenouchi T, Fujita M, Kitani H, Conti B, Hashimoto M
    • Journal Title

      Neuroscience

      Volume: 232 Pages: 13-20

    • DOI

      10.1016/j.neuroscience.2012.12.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-13Ra1 expression in dopaminergic neurons contributes to thier oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide2012

    • Author(s)
      Morrison BE, Marcondes MC, Nomura DK, Sanchez-Alavez M, Sanchez-Gonzalez A, Saar I, Kim KS, Bartfai T, Maher P, Sugama S, Conti B
    • Journal Title

      J Immunol

      Volume: 15 Issue: 12 Pages: 5498-5502

    • DOI

      10.4049/jimmunol.1102150

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a Cells: Involvement of PI3 kinase/Akt signaling pathway.2012

    • Author(s)
      Takenouchi T. et al.
    • Journal Title

      Cell Biol. Int.

      Volume: 36 Issue: 12 Pages: 1223-1231

    • DOI

      10.1042/cbi20120329

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H b-synuclein2012

    • Author(s)
      S ekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Sugama S, Hashimoto M
    • Journal Title

      Neurosci Lett

      Volume: 515(1) Issue: 1 Pages: 97-101

    • DOI

      10.1016/j.neulet.2012.03.037

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Stress-induced microglial activation may be triggered by noradrenergic neurons2015

    • Author(s)
      洲鎌 秀永、柿沼 由彦
    • Organizer
      日本生理学会(第92回)
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 急性拘束ストレスモデルを用いた活性化ミクログリアとcFos発現ニューロンのトポグラフィー分析2014

    • Author(s)
      洲鎌秀永
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島市
    • Related Report
      2013 Research-status Report
  • [Presentation] Corticosteroids limit microglial activation occurring during acute stress2013

    • Author(s)
      洲鎌 秀永
    • Organizer
      日本生理学会(第90回)
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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