| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have demonstrated the first evidence that acute stress could induce morphological microglial activation in the brain. The goal of this study was to investigate the mechanism how the microglial activation is triggeredd by exposures to acute stress. We found that Dopamine beta Hydroxylase (DBH), an enzyme required for the synthesis of noradrenaline in the brain, is significantly elevated in the hippocampus, thalamus, and hypothalamus in response to acute stress. In addition, we found that DBH immunoreactive fibers surround microglial cells. Those microglial cells were found to be positive to beta 1 and beta 2 Adrenergic Receptor (AR). We suggest that microglia may be modulated through noradrenaline during the time of acute stress.
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