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The interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system

Research Project

Project/Area Number 24500473
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fusional basic brain science
Research InstitutionShowa University

Principal Investigator

IIGAYA Kamon  昭和大学, 医学部, 普通研究生 (80445204)

Co-Investigator(Kenkyū-buntansha) ONIMARU Hiroshi  昭和大学, 医学部, 客員教授 (30177258)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords視床下部腹内側核 / 交感神経 / 肥満 / 摂食 / エネルギー調節 / 血圧調節 / 脳神経
Outline of Final Research Achievements

The ventromedial hypothalamus (VMH) is known to play an important role in feeding behavior and sympathetic nerve activity (SNA) control, however, the details of its involvement are unclear. VMH neurons express receptors of various neuropeptides that are involved in the regulation of feeding behavior. We herein report the identification of novel neuron groups that showed oscillations on both sides of the VMH on hypothalamus slice preparations from rats. The application of feeding peptides and changes in extracellular glucose concentration induced frequency changes in VMH oscillation, similar to the changes in the SNA induced by the application of those compounds in brain. The VMH oscillation frequency also corresponded to a low range of heart rate variability which is one of the indexes of SNA. We hypothesize that the VMH oscillation is involved in SNA and that its regulation could be a new strategy for control of energy expenditure and eventually obesity.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 2 results)

  • [Journal Article] Effects of riluzole on respiratory rhythm generation in thebrainstem-spinal cord preparation from newborn rat.2015

    • Author(s)
      Shih Tien Lin, Hiroshi Onimaru
    • Journal Title

      Neuroscience Research

      Volume: 94 Pages: 28-36

    • DOI

      10.1016/j.neures.2014.12.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats.2015

    • Author(s)
      Tsuzawa K, Yazawa I, Shakuo T, Ikeda K, Kawakami K,
    • Journal Title

      Neuroscience

      Volume: 286 Pages: 404-411

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 重症筋無力症にて胸腺腫摘出後ネフローゼ症候群を合併しLDLアフェレシスが著効した1例2014

    • Author(s)
      飯ヶ谷嘉門、今福俊夫、安藤孝、立松覚、黄田宗明、大槻昌子、内藤真規子、亀山香織
    • Journal Title

      日本透析医学会雑誌

      Volume: In press

    • NAID

      130003395201

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of doxapram on medullary respiratory neurones in brainstem-spinal cord preparations from newborn rats.2014

    • Author(s)
      Osaka Y, Onimaru H, Kotani S, Kashiwagi M, Morisaki H, Takeda J.
    • Journal Title

      Anaesthesia

      Volume: 69 Issue: 5 Pages: 468-475

    • DOI

      10.1111/anae.12590

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytoarchitecture and CO2 sensitivity of Phox2b-positive parafacial neurons in the newborn rat medulla.2014

    • Author(s)
      Onimaru H, Ikeda K, Kawakami K
    • Journal Title

      Progress in Brain Research

      Volume: 209 Pages: 57-71

    • DOI

      10.1016/b978-0-444-63274-6.00004-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of dorsolateral periaqueductal grey in the coordinated regulation of cardiovascular and respiratory function.2013

    • Author(s)
      Dampney RA, Furlong TM, Horiuchi J, Iigaya K.
    • Journal Title

      Autonomic Neuroscience: Basic and Clinical

      Volume: 175 Issue: 1-2 Pages: 17-25

    • DOI

      10.1016/j.autneu.2012.12.008

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aldosterone is synthesized in and activates bulbospinal neurons through mineralocorticoid receptors and ENaCs in the RVLM2013

    • Author(s)
      Naoki Oshima, Hiroshi Onimaru, Hanako Takechi, Kojiro Yamamoto, Atsushi Watanabe, Takahiro Uchida, Yasuhiro Nishida, Takashi Oda and Hiroo Kumagai
    • Journal Title

      Hypertension Research

      Volume: 36 Issue: 6 Pages: 1-9

    • DOI

      10.1038/hr.2012.224

    • NAID

      10031189654

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired response to hypoxia in the respiratory center is a main cause of neonatal death of the PACAP knockout mouse2013

    • Author(s)
      Arata Satoru, Nakamachi, Tomoya,Onimaru Hiroshi, Hashimoto Hitoshi and Shioda Seiji
    • Journal Title

      European Journal of Neuroscience

      Volume: 37 Issue: 3 Pages: 407-416

    • DOI

      10.1111/ejn.12054

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses.2012

    • Author(s)
      Iigaya K, Horiuchi J, McDowall LM, Lam AC, Sediqi Y, Polson JW, Carrive P, Dampney RA.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 303(10) Issue: 10 Pages: R1011-R1022

    • DOI

      10.1152/ajpregu.00263.2012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synchronized activation of sympathetic vasomotor, cardiac, and respiratory outputs by neurons in the midbrain colliculi.2012

    • Author(s)
      Iigaya K, ller-Ribeiro FC, Horiuchi J, McDowall LM, Nalivaiko E, Fontes MA, Dampney RA.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 303(6) Issue: 6 Pages: R599-R610

    • DOI

      10.1152/ajpregu.00205.2012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 中脳における交感神経と呼吸機能との相互作用2012

    • Author(s)
      飯ヶ谷嘉門・熊谷裕生
    • Journal Title

      医学のあゆみ

      Volume: 243(5) Pages: 384-391

    • Related Report
      2012 Research-status Report
  • [Journal Article] Baro-excited neurons in the caudal ventrolateral medulla (CVLM) recorded using the whole-cell patch-clamp technique2012

    • Author(s)
      Oshima N, Kumagai H, Iigaya K, Onimaru H, Kawai A, Nishida Y, Saruta T, Itoh H.
    • Journal Title

      Hypertension Research

      Volume: 35(5) Issue: 5 Pages: 500-6

    • DOI

      10.1038/hr.2011.211

    • NAID

      10030645619

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of corticotropin-releasing factor on intermediolateral cell column neurons of newborn rats.2012

    • Author(s)
      Tanabe A., Onimaru H., Suzuki H., Takeyama, Y. and Homma I.
    • Journal Title

      Autonomic Neuroscience: Basic and Clinical

      Volume: 171 Pages: 36-40

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between the distribution of Phox2b expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats2012

    • Author(s)
      Onimaru, H., Ikeda, K., Kawakami, K.
    • Journal Title

      Neuroscience

      Volume: (印刷中) Pages: 131-139

    • DOI

      10.1016/j.neuroscience.2012.03.037

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic mechanisms of CO2 responses in parafacial pre-inspiratory neurons of newborn rats2012

    • Author(s)
      Onimaru, H., Ikeda, K., Kawakami, K.
    • Journal Title

      J.Phys.

      Volume: (印刷中) Issue: 7 Pages: 1615-1624

    • DOI

      10.1113/jphysiol.2011.222687

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure.2012

    • Author(s)
      Kumagai H, Oshima N, Matsuura T, Iigaya K, Imai M, Onimaru H, Sakata K, Osaka M, Onami T, Takimoto C, Kamayachi T, Itoh H, Saruta T.
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 132-141

    • NAID

      10030643268

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Integrative view of respiratory control mechanisms in the pons, medulla and spinal cord.2015

    • Author(s)
      Hiroshi Onimaru, Hidehiko Koizumi.
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] TRPA1 agonist, cinnamaldehyde induced long-lasting facilitation of respiratory rhythm in the brainstem-spinal cord preparation isolated from newborn rat and in the in situ perfused- preparation from juvenile rat.2014

    • Author(s)
      Hiroshi Onimaru, Shih Tien Lin, Mariho Tani, Itaru Yazawa, Keiko Ikeda, Kiyoshi Kawakami
    • Organizer
      Society for Neuroscience 2014 Annual Meeting
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Riluzole depresses burst generation of pre-inspiratory neurons in the rostral medulla of the brainstem-spinal cord preparation from newborn rats.2014

    • Author(s)
      S. LIN, H. ONIMARU
    • Organizer
      Society for Neuroscience 2014 Annual Meeting
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Respiratory rhythm generation in the brainstem-spinal cord preparation of Pax6 mutant rats.2014

    • Author(s)
      Hiroshi Onimaru, Shih Tien Lin, Keiko Ikeda, Noriko Osumi.
    • Organizer
      第37回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel oscillation (burst rhythm) in ventromedial nucleus of the hypothalamus may mediate the sympathetic nerve activity2014

    • Author(s)
      飯ケ谷 嘉門
    • Organizer
      The International Congress of Neuroendocrinology 2014
    • Place of Presentation
      Sydney Australia
    • Year and Date
      2014-08-17 – 2014-08-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] New mechanisms of modulation of respiratory rhythm: Effects of TRP channel related substances.2013

    • Author(s)
      Hiroshi Onimaru
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 重症筋無力症にて胸腺腫摘出後ネフローゼ症候群を合併した1例2012

    • Author(s)
      飯ヶ谷嘉門 今福俊夫 安藤孝 佐々木誠一 黄田宗明 大槻昌子
    • Organizer
      第42回日本腎臓学会東部学術大会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of corticotropin-releasing factor on intermediolateral cell column neurons.2012

    • Author(s)
      Ayaka Tanabe, Hiroshi Onimaru, Hiroshi Suzuki, Yoichi Takeyama.
    • Organizer
      Hypertension
    • Place of Presentation
      Sydney
    • Related Report
      2012 Research-status Report
  • [Presentation] CO2 sensitivity and histological characteristics of Phox2b-positive parafacial neurons in newborn rat medulla.2012

    • Author(s)
      Hiroshi Onimaru, Keiko Ikeda and Kiyoshi Kawakami.
    • Organizer
      The XIIth Oxford Conference
    • Place of Presentation
      Almelo, Netherland
    • Related Report
      2012 Research-status Report
  • [Presentation] 剖検にて嗜銀顆粒性認知症を認めた維持透析患者の1例

    • Author(s)
      飯ケ谷嘉門,今福俊夫,立松覚,内藤真規子 小出隆司、佐々木文、藤ヶ崎純子
    • Organizer
      第58回 日本透析医学会学術集会・総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] オレキシン受容体拮抗薬は視床下部性昇圧反応を減弱させる

    • Author(s)
      飯ヶ谷嘉門、Jouji Horiuchi、 Lachlan McDowall、Alex Lam、 Yusuf Sediqi、 Jamie Polson、 Pascal Carrive、Roger Dampney
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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