| Project/Area Number |
24500475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TSUNEKO Mishima 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (90415307)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRASE Hajime 理化学研究所, 脳科学総合研究センター, 神経グリア回路研究チームリーダー (90392084)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アストロサイト / 可塑性 / 二光子イメージング / ウイルス / 慢性計測 / バレル / AAV9 / 二光子 / in vivo / グリア / シナプス |
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| Outline of Final Research Achievements |
We investigated the role of glial cells in synaptic plasticity by analyzing a change in the microenvironment surrounding neurons occurs plasticity in vivo, in particular the dynamics of glial cells (astrocytes). ①Protocol for induce cortical plasticity under physiological conditions, and to visualize astrocytes surrounding synapses were examined and established. ②Animal fix device development for chronic imaging of astrocytic processes structure using two-photon microscope was achieved. ③Analyzing those imaging data (including making program in Matlab). Consequently astrocytes found to have varied over time form by plasticity induction, the time course is currently being analyzed.
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