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Investigation of possible mechanism for regulation of cerebral blood flow during exercise

Research Project

Project/Area Number 24500478
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fusional brain recording science
Research InstitutionHosei University

Principal Investigator

HIURA Mikio  法政大学, スポーツ健康学部, 教授 (10327918)

Co-Investigator(Kenkyū-buntansha) NARIAI Tadashi  東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (00228090)
ISHII Kenji  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (10231135)
Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Katsumi  神奈川工科大学, 創造工学部, 教授 (30267637)
Research Collaborator MUTA Akitaka  東京医科歯科大学, 医歯(薬)学総合研究科
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords陽電子放出断層撮像法 / 脳血流 / 運動 / PET / cerebral blood flow / exercise / brain function / 局所脳血流量 / 運動負荷
Outline of Final Research Achievements

We investigated changes in regional cerebral blood flow (rCBF) during cycling ergometer which was continued at low intensity. Main findings of this research project are; 1) Distribution of increased rCBF during exercise was differed between the onset and a later phase of exercise. Afferent neural impulse from working muscles in lower limbs and central command would have a role in regulation of rCBF during exercise. 2) rCBF reduced after exercise secession by 16 %, approximately, in several regions such as posterior cingulate gyrus. 3) The similar type of exercise as evaluated in the PET study induced changes in regional oxygennation which were distinct from the tendency of those in rCBF.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Changes in cerebral blood flow during steady-state cycling exercise: a study using oxygen-15-labeled water with PET2014

    • Author(s)
      Hiura, M. Nariai, T. Ishii, K. Sakata, M. Oda, K. Toyohara, J. Ishiwata, K.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 34 Issue: 3 Pages: 389-396

    • DOI

      10.1038/jcbfm.2013.220

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Decreased regional cerebral blood flow evoked by dynamic exercise; A positron emission tomography study2015

    • Author(s)
      Mikio, M., Nariai T., Ishii K., Sakata K., Oda K., Toyohara J., Ishiwata K.
    • Organizer
      XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIIth International Conference
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2015-06-27 – 2015-07-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of cerebral blood flow and oxygenation in frontal cortex during exercise2015

    • Author(s)
      Mikio Hiura, Katsumi Takahashi, Muneyuki Skakata, Kenji Ishii, Keiichi Oda, Jun Toyohara, Akitaka Muta, Tadashi Nariai, Kiichi Ishiwata
    • Organizer
      Organization for Human Brain Mapping 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-06-14 – 2015-06-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exercise-induced positive activated affect is dependent on work intensity and modulated by opioid receptor system distributed in the mesolimbic pathway. A positron emission tomography study2014

    • Author(s)
      Mikio, M., Nariai T., Ishii K., Sakata K., Oda K., Toyohara J., Ishiwata K.
    • Organizer
      Neuroscience2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 運動に伴う気分変化の発現機構の検討:中脳辺縁系におけるオピオイド受容体系の関与について2014

    • Author(s)
      日浦幹夫、成相直、石井賢二、坂田宗之、織田圭一、豊原潤、石渡喜一
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Physiological correlates of cerebral blood flow at the onset of the steady-state excercise: a PET study.2013

    • Author(s)
      Hiura, M., Nariai, T., Ishii, K., Sakata, M., Oda, K., Toyohara, J., Ishiwata, K.
    • Organizer
      11th International Conference on Quantification of Brain Function with PET (BrainPET ’13)
    • Place of Presentation
      Shanghai, China, Shanghai International Convention Center
    • Related Report
      2013 Research-status Report
  • [Presentation] 定常運動負荷時の脳循環調節機構について:H215OPET脳血流計測を用いた考察2013

    • Author(s)
      日浦幹夫、成相直、石井賢二、坂田宗之、織田圭一、豊原潤、石渡喜一
    • Organizer
      第25回日本脳循環代謝学会総会
    • Place of Presentation
      札幌、京王プラザホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] Physiological correlates of cerebral blood flow at the onset of the steady-state exercise: a PET study2013

    • Author(s)
      Hiura Mikio
    • Organizer
      The XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Shanghai International Convention Center, Shanghai, China
    • Related Report
      2012 Research-status Report
  • [Presentation] Changes in regional cerebral blood flow during light intensity exercise of cycle ergometer2012

    • Author(s)
      Hiura Mikio
    • Organizer
      the 16th European Federation of Neurological Society (EFNS) Congress
    • Place of Presentation
      Stockholmsmassan, Stockholm, Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] PET計測による自転車エルゴメーター運動負荷時の局所脳血流量変化の検討2012

    • Author(s)
      日浦幹夫
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌、札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 定常運動負荷中のPET計測による脳血流量の検討:運動開始時と継続中の相違点の考察2012

    • Author(s)
      日浦幹夫
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      リーガロイヤルホテル広島、広島
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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