Establishment of a new model rat for immunological diseases deleting the Ly49 gene regulating immune reactions
Project/Area Number |
24500484
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Hirosaki University |
Principal Investigator |
YAMADA Toshiyuki 弘前大学, 医学(系)研究科(研究院), 准教授 (20183981)
|
Co-Investigator(Kenkyū-buntansha) |
TSUCHIDA Shigeki 弘前大学, 医学研究科, 教授 (20142862)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 弘前ヘアレスラット / 胸腺 / 制御性T細胞 / B1-B細胞 / Ly49s3遺伝子 / 弘前へアレスラット / ヘルパーT細胞 / 胸腺樹状細胞 / ビタミンA / 樹状細胞 / ケモカイン |
Outline of Final Research Achievements |
The Hirosaki hairless rats (HHRs) exhibit immunological abnormalities in their thymus such as differentiation inhibition of regulatory T (Treg) cells and unusual presence of mature B cells, which appear to be B1-B cells. HHR also shows symptoms of autoimmune diseases that are thought to be results of its immunological abnormalities. In this study, we showed that HHR deletes the Ly49s3 gene, regulating cell-cell interactions of immunological cells and normally expressed in thymic dendritic cells, and that functional failure of HHR thymic dendritic cells due to loss of the expression of the gene is the reason for the immunological abnormalities in HHR.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan2015
Author(s)
Sawano T, Shimizu T, Yamada T, Nanashima N, Miura T, Morohashi S, Kudo D, Hui F-M, Kijima H, Hakamada K, Tsuchida S
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Journal Title
Oncology Reports
Volume: 33
Pages: 2151-2160
DOI
Related Report
Peer Reviewed / Open Access
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