| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The Hirosaki hairless rats (HHRs) exhibit immunological abnormalities in their thymus such as differentiation inhibition of regulatory T (Treg) cells and unusual presence of mature B cells, which appear to be B1-B cells. HHR also shows symptoms of autoimmune diseases that are thought to be results of its immunological abnormalities. In this study, we showed that HHR deletes the Ly49s3 gene, regulating cell-cell interactions of immunological cells and normally expressed in thymic dendritic cells, and that functional failure of HHR thymic dendritic cells due to loss of the expression of the gene is the reason for the immunological abnormalities in HHR.
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