Sox17 haploinsufficiency as applied to human disease model for newborn hepatitis.
Project/Area Number |
24500485
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
KANAI MASAMI 東京医科歯科大学, 実験動物センター, 教授 (70321883)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | へテロ不全 / 疾患モデル動物 / 新生児肝炎 / Sox17 / ヘテロ不全 / TARGATT / マウス / 胆のう / C57BL/6 / 疾患モデルマウス / 肝炎 / 先天性疾患 |
Outline of Final Research Achievements |
In this study, we have observed the phenotype about the condition of a patient of the newborn hepatitis that showing Sox17 haploinsufficiency comparative with Sox17 conditional knockout lines for liver, pancreas and gallbladder, morphologically. In addition, as a candidate of the new human disease model, we confirmed gene introduction efficiency by use of TARGATT (the transgenic mouse system which can control a copy number in site specific). We will apply it as a disease model compared with Sox17 heterozygous mouse and point mutated SHIVA mouse (Met 72 mutated to Arg; with the liver metabolism abnormality symptom).
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice2013
Author(s)
Uemura. Mami., Ozawa A. Nagala T. Kurosawa K., Tsurukawa. K., Nobuhisa I., Taka T. Mara. K., Kudo, A., Kawakami. H., Saijoh. Y. Kurohmaru M. Kanai, Azuma. M., Kanai. Yoshiakira.
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Journal Title
Development
Volume: 140
Issue: 3
Pages: 639-648
DOI
Related Report
Peer Reviewed
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