| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate pathogenesis of autoimmune diseases (autoimmune type 1 diabetes and autoimmune thyroiditis) in animal models by comprehensive longitudinal metabolomic profiling. From the viewpoint of metabolome, metabolites and metabolic pathways which are involved in the pathogenesis of autoimmune diseases were identified. Novel biomarker candidates which reflect the state of diseases were also found. These results could lead to the development of novel diagnosis and evaluation methods of autoimmune diseases.
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