| Project/Area Number |
24500496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
OKADA Toshiya 大阪府立大学, 生命環境科学研究科(系), 教授 (00169111)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAMOTO Masafumi 大阪府立大学, 生命環境科学研究科, 教授 (80231629)
NAKAGAWA Hiroshi 大阪府立大学, 生命環境科学研究科, 助教 (60336807)
KONDO Tomohiro 大阪府立大学, 生命環境科学研究科, 助教 (40585238)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUYAMA Satoshi 大阪府立大学, 生命環境科学研究科, 准教授 (10254442)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 遺伝解析 / 眼内炎 / 細胞増殖因子 / 疾患モデル動物 / 水晶体破裂 / Bcar3 / 疾患モデルマウス / 水晶体破裂白内障 / 水晶体上皮 / 熱ショック蛋白 / FGF / 水晶体上皮細胞 / 常染色体劣性遺伝 |
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| Outline of Final Research Achievements |
In the inherited lens rupture cataract mouse model derived from CF#1 mice (CF#1/lr mice), the white pin head opacity is the first sign of lens rupture. Then, the opacity becomes enlarged and finally results in an entirely white eye. The lens rupture is induced by abnormality of gene (Bcar3) related to the breast cancer. Although lens rupture is often complicated by endophthalmitis, CF#1/lr mice do not develop endophthalmitis. The levels of αB crystallin, one of the heat shock proteins protecting lens, and phosphorylated αB crystallin (PαB crystallin) which is increased by stress were decreased in the lens of CF#1/lr mice. This may be related to the characteristics of CF#1/lr mice do not develop endophthalmitis despite lens rupture.
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