| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Pasteurella pneumotropica is an opportunistic pathogen for rodents and is one of preventive pathogens for managing health of laboratory animals. The objectives of this study were to identify virulence associations and to clarify relationships between P. pneumotropica pathogenesis and host cell response. In this study, additional RTX toxin, IbpA and YadA were identified in P. pneumotropica. Of these, IbpA is involved in tyrosine-phosphorylation in murine macrophage cells by the Src family kinase. YadA is indispensable for adherent against host fibroblast cells and extracellular matrix. These virulence associations are required for P. pneumotropica pathogenesis.
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