Identification of virulence associations and host response in Pasteurella pneumotropica.
| Project/Area Number |
24500497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Juntendo University (2013-2015)
Tokyo Medical University (2012) |
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Principal Investigator |
Sasaki Hiraku 順天堂大学, スポーツ健康科学部, 准教授 (20384969)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAMOTO Eiichi 東京医科大学, 医学部, 准教授 (20074718)
ISHIKAWA Hiroki 東京医科大学, 医学部, 助教 (60433918)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 肺パスツレラ / リン酸化 / ドラフトゲノム / ドラフトゲノム解析 / 赤血球凝集素 / YadA / RTX toxin / IbpA / 細菌毒素 / 日和見病原体 / 感染症 |
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| Outline of Final Research Achievements |
Pasteurella pneumotropica is an opportunistic pathogen for rodents and is one of preventive pathogens for managing health of laboratory animals. The objectives of this study were to identify virulence associations and to clarify relationships between P. pneumotropica pathogenesis and host cell response. In this study, additional RTX toxin, IbpA and YadA were identified in P. pneumotropica. Of these, IbpA is involved in tyrosine-phosphorylation in murine macrophage cells by the Src family kinase. YadA is indispensable for adherent against host fibroblast cells and extracellular matrix. These virulence associations are required for P. pneumotropica pathogenesis.
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Report
(5 results)
Research Products
(17 results)
