Diffuse Correlation Imaging for Diagnosis of Biological Tissue
| Project/Area Number |
24500504
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIMURA Goro 北海道大学, 電子科学研究所, 助教 (30218193)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | diffuse correlation / photon correlation / photon counting / fluorescence correlation / tissue diagnosis / 拡散干渉分光法 / 光子相関法 / 蛍光相関法 / 生体分光法 |
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| Outline of Final Research Achievements |
The project aimed to establish a diagnosis technology by means of diffuse correlation imaging. In the project, a multi-point high time-resolution photon counting system was constructed for a multiple correlation analysis of the scattering photon through biological tissue. In addtion, a time-resolved system for the scattering photon was combined to determin optical parameters such as the absorption and scattering coefficients. The system was successifully applied for measurements of phantom and rat abnodominal tissue, yielding the scattering, absorption coefficients and correlation time, which carries the information of tissue structure, blood absorption and blood flow, respectively. Finally, the 2D image could be obtained to visualize these parameters. This novel technology will extend current optical methods for diagnosis of biological tissue.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] In vivo multi-modal cellular imaging with emission tunable 2nd near-infrared quantum dots2013
Author(s)
Y.Tsukazaki,Y.Mori,Y.Ohyanagi,Y.Nakane,M.Hasegawa,Q.Ma,T.Sakata,H.Yasuda,Y.Watanabe,Y.Yoshikawa,G.Nishimura,T.Jin
Organizer
日本光学会年次学術講演会(OPJ2013)
Place of Presentation
奈良県新公会堂、奈良市、奈良県
Related Report
Invited
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