• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Diffuse Correlation Imaging for Diagnosis of Biological Tissue

Research Project

Project/Area Number 24500504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

NISHIMURA Goro  北海道大学, 電子科学研究所, 助教 (30218193)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsdiffuse correlation / photon correlation / photon counting / fluorescence correlation / tissue diagnosis / 拡散干渉分光法 / 光子相関法 / 蛍光相関法 / 生体分光法
Outline of Final Research Achievements

The project aimed to establish a diagnosis technology by means of diffuse correlation imaging. In the project, a multi-point high time-resolution photon counting system was constructed for a multiple correlation analysis of the scattering photon through biological tissue. In addtion, a time-resolved system for the scattering photon was combined to determin optical parameters such as the absorption and scattering coefficients. The system was successifully applied for measurements of phantom and rat abnodominal tissue, yielding the scattering, absorption coefficients and correlation time, which carries the information of tissue structure, blood absorption and blood flow, respectively. Finally, the 2D image could be obtained to visualize these parameters. This novel technology will extend current optical methods for diagnosis of biological tissue.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Presentation (11 results) (of which Invited: 4 results)

  • [Presentation] Near-infrared fluorescence fluctuation measurement system - Its design and applications2015

    • Author(s)
      西村 吾朗
    • Organizer
      The 5th Asian and Pacific-Rim Symposium on Biophotonics (APBP`15)
    • Place of Presentation
      Pacifico Yokohama(神奈川県・横浜市)
    • Year and Date
      2015-04-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] FPGAを用いた光子計数システムによる 光子相関測定2014

    • Author(s)
      西村 吾朗
    • Organizer
      日本光学会年次学術講演会(OPJ2014)
    • Place of Presentation
      筑波大学東京キャンパス文京校舎(東京都・文京区)
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] A photon-timing recorder in a nano-second resolution and its application for near-infrared fluorescence fluctuation measurements2014

    • Author(s)
      西村 吾朗
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 光のゆらぎ計測とその応用2014

    • Author(s)
      西村 吾朗
    • Organizer
      第9回レーザー学会「レーザーバイオ医療」技術専門委員会
    • Place of Presentation
      北海道大学学術交流会館(北海道・札幌市)
    • Year and Date
      2014-06-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 一般化パルススペクトル法を用いた蛍光トモグラフィーの3次元画像再構成2014

    • Author(s)
      竹越雅史、大川晋平、正本和人、西村吾朗、山田幸生
    • Organizer
      第26回日本機械学会バイオエンジニアリング講演会
    • Place of Presentation
      東北大学、片平キャンパス、仙台市、宮城県
    • Related Report
      2013 Research-status Report
  • [Presentation] Tissue optical properties in an 1-um wavelength region2014

    • Author(s)
      西村吾朗
    • Organizer
      第15回光科学技術で拓く脳・精神科学平和探求研究会
    • Place of Presentation
      ホテルクラウンパレス浜松、浜松市、静岡県
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 光安定性の高い近赤外蛍光イメージング用ナノ粒子造影剤の創製2014

    • Author(s)
      牧野顕、古川大介、Kamlesh Awasthi、天満敬、小野正博、西村吾朗、佐治英郎
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学、熊本市、熊本県
    • Related Report
      2013 Research-status Report
  • [Presentation] 3次元時間分解型拡散トモグラフィにおける精度向上に向けた検討2013

    • Author(s)
      古川大介、Kamlesh Awasthi、西村吾朗
    • Organizer
      日本光学会年次学術講演会(OPJ2013)
    • Place of Presentation
      奈良県新公会堂、、奈良市、奈良県
    • Related Report
      2013 Research-status Report
  • [Presentation] In vivo multi-modal cellular imaging with emission tunable 2nd near-infrared quantum dots2013

    • Author(s)
      Y.Tsukazaki,Y.Mori,Y.Ohyanagi,Y.Nakane,M.Hasegawa,Q.Ma,T.Sakata,H.Yasuda,Y.Watanabe,Y.Yoshikawa,G.Nishimura,T.Jin
    • Organizer
      日本光学会年次学術講演会(OPJ2013)
    • Place of Presentation
      奈良県新公会堂、奈良市、奈良県
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Non-contact type time-domain fluorescence diffuse optical tomography for quantitative analysis of fluorophores2013

    • Author(s)
      Goro Nishimura, Daisuke Furukawa, Kamlesh Awasthi
    • Organizer
      BiOS, Photonics West 2013
    • Place of Presentation
      The Moscone Center, San Francisco, CA, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 散乱体中での蛍光寿命測定2012

    • Author(s)
      西村吾朗、カムレス・アワスティ、古川大介
    • Organizer
      日本光学会年次学術講演会(OPJ2012)
    • Place of Presentation
      タワーホール船堀、東京都江戸川区
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi