| Project/Area Number |
24500508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto Prefectural University of Medicine (2014-2015)
Kyoto University (2012-2013) |
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Principal Investigator |
Sakai Koji 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20379027)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Kei 京都府立医科大学, 大学院医学研究科放射線診断治療学, 教授 (80315960)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | DWI-thermometry / 脳 / 側脳室 / 温度 / パーキンソン病 / 多系統萎縮 / 生理周期 / 外傷性脳損傷 / 磁気共鳴像 / 多系統萎縮症 / 拡散 / くも膜下出血 / 精神疾患 / トラウマ / 多発性硬化症 / 拡散強調画像 |
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| Outline of Final Research Achievements |
This study aimed to provide a novel index of brain activity as temperature by analyzing one of MRI modality which named diffusion weighted image (DWI). DWI has already been included in routine MRI acquisition, therefore, no additional acquisition cost for patients. We optimized DWI parameters by phantom study and built a analysis method to calculate temperature from DWI. These methodology were applied for both healthy subjects and patients: multiple sclerosis, schizophrenia, bipolar disorder, mild traumatic brain injury, Parkinson’s disease, multiple system atrophy, idiopathic normal pressure hydrocephalus, and subarachnoid hemorrhage. There were clear difference between patients and healthy subjects on deep brain temperature. These results might suggest that brain activity of these patients were lower than normal condition. The details of the mechanisms need further investigation.
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