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Composite imaging method for histological image analysis

Research Project

Project/Area Number 24500514
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionShibaura Institute of Technology

Principal Investigator

TAKAHASHI Masanobu  芝浦工業大学, システム工学部, 教授 (20338312)

Co-Investigator(Kenkyū-buntansha) NAKANO Masayuki  横浜市立大学, 医学部, 教授 (00092073)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords画像解析 / 診断支援 / 病理診断 / 病理組織 / 暗視野 / 位相差 / 光学顕微鏡 / 肝臓 / 顕微鏡
Outline of Final Research Achievements

A composite imaging method has been developed that enables the user to directly capture a composite image by one-image capturing. The composite images of bright-field, dark-field, and phase-contrast images can be captured with an arbitrary composition ratio. Both different channels of different capturing methods and two dark-field images with different illumination directions can also be captured by one-image capturing. Three kinds of images and their composite images were useful to improve both the visibility and the accuracy for extracting Helicobacter pylori in HE-stained gastric histological sections. Those images were also useful for improving the visibility and the accuracy for image analysis of both HE-stained and unstained liver sections. A method for estimating and visualizing the distributions of features in hepatic histological sections was also developed. A part of developed functions were introduced in a diagnosis support system to extract useful features.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (47 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (37 results) (of which Invited: 7 results) Book (4 results)

  • [Journal Article] 肝細胞癌の多中心性発生と肝内転移2015

    • Author(s)
      中野雅行
    • Journal Title

      日本臨床 最新肝癌学

      Volume: 1071 Pages: 302-306

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Automatic calculation and visualization of nuclear density in whole slide images of hepatic histological sections2015

    • Author(s)
      Akito Nagase, Masanobu Takahashi, Masayuki Nakano
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cirrhosis”の可逆性に関する考察2014

    • Author(s)
      中野雅行
    • Journal Title

      肝胆膵

      Volume: 68 Pages: 705-708

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 未浸潤早期肝細胞癌(preinvasive early hepatocellular carcinoma)の病理2013

    • Author(s)
      中野雅行、佐野勝廣、市川智章、本杉宇太郎、曹 博信、荒木 力、松田政徳、藤井秀樹
    • Journal Title

      第18回肝血流動態イメージ研究会記録集

      Volume: なし Pages: 25-29

    • Related Report
      2012 Research-status Report
  • [Journal Article] 肝生検における早期肝細胞癌の門脈域浸潤組織像の多彩性2012

    • Author(s)
      中野雅行、吉田篤史、清水弘仁、松井圭司、藤川智章、松永光太郎、岩渕省吾
    • Journal Title

      Liver Cancer

      Volume: 18 Pages: 53-60

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 細胆管細胞癌、幹細胞との関連2012

    • Author(s)
      中野雅行
    • Journal Title

      外科

      Volume: 74 Pages: 1152-1156

    • Related Report
      2012 Research-status Report
  • [Presentation] 前駆細胞(progenitor cells)からみた肝癌2014

    • Author(s)
      中野雅行
    • Organizer
      第29回千波湖肝カンファランス
    • Place of Presentation
      水戸プラザホテル(茨城)
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 混合型肝癌―肝癌取り扱い規約をベースに2014

    • Author(s)
      中野雅行
    • Organizer
      第50回肝癌症例検討会基調講演
    • Place of Presentation
      東京
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Vascularization of hepatocellular adenomas and carcinomas by bo-option o portal tracts2014

    • Author(s)
      Ashely E, Stueck, Masayuki Nakano, Ian R. Wanless
    • Organizer
      65th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      ボストン(英国)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Visualization of Features in Digital Slides of HE-Stained Hepatic Histological Sections2014

    • Author(s)
      Masanobu Takahashi, Tomofumi Fujii, Masayuki Nakano
    • Organizer
      The XXXth Congress of the International Academy of Pathology 2014 (IAP2014)
    • Place of Presentation
      バンコク(タイ)
    • Year and Date
      2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Multimodal Image Analysis of Unstained Histological Sections2014

    • Author(s)
      Takuya Ushikawa, Masanobu Takahashi, Masayuki Nakano
    • Organizer
      6th European Conference of the International Federation for Medical and Biological Engineering (MBEC2014)
    • Place of Presentation
      ドゥブロブニク(クロアチア)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 無染色肝病理組織標本の画像解析2014

    • Author(s)
      牛川卓弥,高橋正信,中野雅行
    • Organizer
      FIT2014(第13回情報科学技術フォーラム)
    • Place of Presentation
      筑波大学
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肝細胞腺腫の最新病理事情 NY5月HCA Workshopを踏まえて2014

    • Author(s)
      中野雅行
    • Organizer
      第3回四国肝疾患病理セミナー
    • Place of Presentation
      香川
    • Year and Date
      2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肝細胞腺腫 第2報Natural history2014

    • Author(s)
      中野雅行
    • Organizer
      第28回千波湖肝カンファランス
    • Place of Presentation
      水戸
    • Year and Date
      2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] New Histological Interpretation on Hepatocellular Adenoma Portal tract mesenchymal destruction, MMP-9 play an important role2014

    • Author(s)
      Masayuki Nakano
    • Organizer
      Laennec annual meeting 2014
    • Place of Presentation
      ニューヨーク(米国)
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期肝細胞癌はどこまで診断できるのか 病理形態からの挑戦2014

    • Author(s)
      中野雅行
    • Organizer
      第49回肝癌症例検討会基調講演
    • Place of Presentation
      秋葉原コンベンションホール(東京)
    • Year and Date
      2014-04-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 無染色標本の撮像および解析2014

    • Author(s)
      宮本啓太、高橋正信、中野雅行
    • Organizer
      電子情報通信学会総合大会
    • Place of Presentation
      新潟大学(新潟)
    • Related Report
      2013 Research-status Report
  • [Presentation] バーチャルスライドの特徴量抽出と可視化2014

    • Author(s)
      藤井智郁、高橋正信、中野雅行
    • Organizer
      電子情報通信学会総合大会
    • Place of Presentation
      新潟大学(新潟)
    • Related Report
      2013 Research-status Report
  • [Presentation] ミニレクチャー "Scalloped HCC" "扇型肝細胞癌" "Scalloped margin nodular HCC"2014

    • Author(s)
      中野雅行
    • Organizer
      第20回肝血流動態・機能イメージ研究会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 肝細胞腺腫の亜分類の新しい考え方2014

    • Author(s)
      中野雅行
    • Organizer
      第20回肝血流動態・機能イメージ研究会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Composite Imaging Method for Histological Image Analysis2013

    • Author(s)
      Mizuho Imai, Akane Takei, Keita Miyamoto, Masanobu Takahashi, Masayuki Nakano
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] 明視野・暗視野・位相差の合成撮像法2013

    • Author(s)
      今井瑞穂、宮本啓太、高橋正信、中野雅行
    • Organizer
      第12回情報科学技術フォーラム
    • Place of Presentation
      鳥取大学(鳥取)
    • Related Report
      2013 Research-status Report
  • [Presentation] EOB-MRIの非特異的所見(HCCであ るのにlowでない)2013

    • Author(s)
      中野雅行、森阪裕之、本杉宇太郎、市川智章
    • Organizer
      第36回Liver Disease Working Group(基臨の会)
    • Place of Presentation
      帝京大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪肝の基礎:生化学から電顕、光顕、肉眼まで2013

    • Author(s)
      中野雅行
    • Organizer
      超音波学会第86回学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 早期肝細胞癌の発育進展の特異性"conversion growth"2013

    • Author(s)
      中野雅行
    • Organizer
      第26回千波湖肝カンファランス
    • Place of Presentation
      ホテル ザ ウエストヒルズ(水戸)
    • Related Report
      2013 Research-status Report
  • [Presentation] 早期肝細胞癌の組織像からみた発育進展に関する新解釈2013

    • Author(s)
      中野雅行
    • Organizer
      第10回日本病理学会カンファレンス2013六甲山セミナー
    • Place of Presentation
      六甲山ホテル(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] 早期肝細胞癌のEOB-MRI画像所見およびOATP1B3発現の不均一性が意味すること2013

    • Author(s)
      中野雅行、森阪裕之、本杉宇太郎、市川智章
    • Organizer
      第2回四国肝疾患病理セミナー
    • Place of Presentation
      アルファーあなぶきホール(香川)
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝細胞腺腫の”癌”とは違った門脈域の破壊2013

    • Author(s)
      中野雅行
    • Organizer
      第4回肝臓よろず勉強会
    • Place of Presentation
      静岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 細胞レベルからみた混合型肝癌(intermediate type)の考察2013

    • Author(s)
      中野雅行
    • Organizer
      第37回 Liver Disease Working Group(基臨の会)
    • Place of Presentation
      帝京大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Heterogeneous intensity at EOB-MRI of early hepatocellular carcinma (HCC) is associated with heterogenous OATP1B3 expression2013

    • Author(s)
      Masayuki Nakano
    • Organizer
      64th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      ワシントンDC (米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝細胞腺腫の組織構造:門脈域間質の破壊2013

    • Author(s)
      中野雅行
    • Organizer
      第27回千波湖肝カンファランス
    • Place of Presentation
      ホテル ザ ウエストヒルズ(水戸)
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝の結節性病変の病理、特に肝細胞結節2013

    • Author(s)
      中野雅行
    • Organizer
      静岡がんセ ンター専門病理医養成研修会第3回
    • Place of Presentation
      サンパレスホテル(静岡)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 合成撮像法の基礎検討2013

    • Author(s)
      宮本啓太、今井瑞穂、高橋正信、中野雅行
    • Organizer
      電子情報通信学会総合大会
    • Place of Presentation
      岐阜大学(岐阜)
    • Related Report
      2012 Research-status Report
  • [Presentation] 病理診断支援のための肝細胞核の自動選別2013

    • Author(s)
      藤井智郁、高橋正信、中野雅行
    • Organizer
      電子情報通信学会総合大会
    • Place of Presentation
      岐阜大学(岐阜)
    • Related Report
      2012 Research-status Report
  • [Presentation] 病理組織標本の合成撮像法2013

    • Author(s)
      今井瑞穂、宮本啓太、高橋正信
    • Organizer
      電子情報通信学会東京支部学生会研究発表会
    • Place of Presentation
      東京電機大学(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Precise Segmentation of Nuclei in Hepatic Histological Images2012

    • Author(s)
      Tomofumi Fujii, Masanobu Takahashi, Kousuke Yamada, Masayuki Nakano
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering 2012
    • Place of Presentation
      北京(中国)
    • Related Report
      2012 Research-status Report
  • [Presentation] Multimodal Method for Extracting Nuclei in Hepatic Histological Images2012

    • Author(s)
      Kenta Miyamoto, Masanobu Takahashi, Jumpei Koichi, Takuya Kitani, Masayuki Nakano
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering 2012
    • Place of Presentation
      北京(中国)
    • Related Report
      2012 Research-status Report
  • [Presentation] Preinvasive early HCC2012

    • Author(s)
      Masayuki Nakano
    • Organizer
      Annual Meeting of the Laennec Liver Pathology Society Meeting
    • Place of Presentation
      ハイデルベルク(ドイツ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Victoria blue染色から見た Hepatocellular adenoma (HCA) の early HCC とは異なる特徴的な門脈域所見2012

    • Author(s)
      中野雅行
    • Organizer
      第34回 Liver Disease Working Group
    • Place of Presentation
      日本大学医学部(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] 最近の肝臓病理の話題 Beyond Cirrhosis2012

    • Author(s)
      中野雅行
    • Organizer
      第1回四国肝疾患病理セミナー
    • Place of Presentation
      アルファあなぶきホール(高松)
    • Related Report
      2012 Research-status Report
  • [Presentation] 最近の肝臓病理の動向 肝硬変、肝細胞癌の考え方2012

    • Author(s)
      中野雅行
    • Organizer
      第25回千波湖肝カンファランス
    • Place of Presentation
      ホテル テラス ザ ガーデン(水戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] 最近の肝臓病理(肝硬変、肝細胞癌)の動向2012

    • Author(s)
      中野雅行
    • Organizer
      第39回神奈川肝臓病理研究会
    • Place of Presentation
      崎陽軒本店(横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] “EOB-MRI low の結節” の病理組織診断の追求 Dysplastic Nodule と Early HCC の鑑別の追求2012

    • Author(s)
      中野雅行
    • Organizer
      第39回日本肝臓学会東部会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Related Report
      2012 Research-status Report
  • [Book] EOB-MRI/Sonazoid 超音波による肝癌の診断と治療2013

    • Author(s)
      中野雅行(工藤正俊、国分茂博編)
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] B型肝炎の診療を極める2013

    • Author(s)
      中野雅行(田中榮司、他編)
    • Publisher
      文光堂
    • Related Report
      2013 Research-status Report
  • [Book] NASH・アルコール性肝障害の診療を極める2013

    • Author(s)
      中野雅行(竹井謙之、他編)
    • Publisher
      文光堂
    • Related Report
      2013 Research-status Report
  • [Book] 肝癌診療Q&A2013

    • Author(s)
      中野雅行(池田健次)
    • Publisher
      中外医学社
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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