Analysis of temperature dependence of fat proton magnetic resonance signal for quantitative temperature imaging

• Project/Area Number: 24500516
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokai University
• Principal Investigator: KURODA Kagayaki 東海大学, 情報理工学部, 教授 (70205243)
• Co-Investigator(Kenkyū-buntansha): IMAI Yutaka 東海大学, 医学部, 教授 (70138113)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: MRI / 温度 / 非侵襲 / 画像 / 脂肪 / T1 / メチレン / 信号 / 磁気共鳴 / 画像化 / 依存性 / プロトン / 集束超音波 / 緩和時間

Outline of Final Research Achievements

In order to execute high intensity focused ultrasound (HIFU) therapy for breast and bone marrow safely and effectively, we planned to establish a noninvasive and quantitative temperature imaging technique using spin-lattice relaxation time (T1) of proton of methylene chain observed by magnetic resonance imaging (MRI). Based on a new finding that the signal intensity ratio of the chemical shift components of fatty acid in bovine and porcine tissues is insensitive to temperature, we have proposed a novel T1 estimation technique using the ratio among the nine fat signal components as a prior knowledge in the image processing following multiple-point Dixon and multiple flip angle imaging. The usefulness and robustness of the technique was demonstrated with numerical simulation.

Research Products

• [Journal Article] Quality assurance: Recommended guidelines for safe heating by capacitive-type heating technique to treat patients with metallic implants (2013)
  • Author(s): Kato H, Kondo M, Imada H, Kuroda M, Kamimura Y, Saito K, Kuroda K, Ito K, Takashi H, Matsuki H
  • Journal Title: Int J Hyperthermia Volume: 29(3) Issue: 3 Pages: 194-205
  • DOI: 10.3109/02656736.2013.774059
  • Peer Reviewed
• [Journal Article] Feasibility of noninvasive temperature imaging of fat based on magnetic resonance relaxation times of lipid proton components (2012)
  • Author(s): Kuroda K, Morita S, Lam MK, Obara M, Baron P, Bartels W, Honda M, Horie H, Imai Y.
  • Journal Title: Thermal Medicine Volume: 28(4) Pages: 87-96
  • Peer Reviewed
• [Presentation] Signal processing for noninvasive temperature imaging of fat and aqueous tissues using methylene T1 and water proton resonance frequency (2014)
  • Author(s): Morita S, Obara M, Honda M, Imai Y, Kuroda K
  • Organizer: Proc 10th Interventional MRI Symposium 2014(P-37):p.126
  • Place of Presentation: The Westin Leiptig, Leiptig, Germany
  • Year and Date: 2014-10-10 – 2014-10-11
• [Presentation] Signal Processing for Noninvasive Temperature Imaging of Fat using Spin-Lattice relaxation time of Proton Magnetic Resonance (2014)
  • Author(s): Morita S, Lam MK, Bartels W, Imai Y, Kuroda K
  • Organizer: Proc 6th Asian Congress of Hyperthermic Oncology & 31st Japanese Congress of Thermal Medicine, Thermal Medicne, Thermal Medicine 2014; 30(Supplement):p. 85
  • Place of Presentation: AOSSA Fukui, Fukui, Japan
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] 脂肪組織プロトン磁気共鳴のスピン格子緩和時間による非侵襲温度分布画像化における信号処理法の検討 (2013)
  • Author(s): 森田修平, Mie Kee Lam, Wilbert Bartels, 今井 裕, 黒田 輝
  • Organizer: 日本ハイパーサーミア学会第30回大会
  • Place of Presentation: 横浜シンポジア（横浜市）
• [Presentation] 脂肪プロトン成分信号のT1による温度分布画像化における信号処理法の検討 (2013)
  • Author(s): 森田修平, Mie Kee Lam, Wilbert Bartels, 今井 裕, 黒田 輝
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: アスティ徳島（徳島市）
• [Presentation] Noninvasive Magnetic Resonance Temperature Imaging (2013)
  • Author(s): Kagayaki Kuroda
  • Organizer: Biomedical Engineering International Conference 2013 (BMEiCON2013)
  • Place of Presentation: Krabi, Thailand
  • Invited
• [Presentation] Proton Density Ratio Consideration in Optimizing Image Processing in Fat-Water Thermometry using Methylene T1 and Water Resonance Frequency (2012)
  • Author(s): Kuroda K, Takano Y, Obara M, Baron P, Lam MK, Bartels WL, Masatoshi H, Imai Y
  • Organizer: Proc 20 th Annual Meeting Intl Soc Mag Reson Med 2012;20:p. 1562
  • Place of Presentation: Melbourne Convention & Exhibition Centre (Melbourne, Australia)
• [Presentation] Temperature dependence of magnetic resonance signals of lipid proton components and its application to fat thermometry (2012)
  • Author(s): Kuroda K, Morita S, Albarodi K, Obara M, Baron P, Lam MK, Bartels W, Honda M, Horie T, Imai Y
  • Organizer: Thermal Medicine , Proc The 11th International Congress of Hyperthermic Oncology (ICHO) and The 29th Japanese Congress of Themal Medicine (JCTM) 2012;28(Suppl):p. 137
  • Place of Presentation: ハイアットリージェンシー京都（京都府）
• [Presentation] Progress in noninvasive MR thermometry (2012)
  • Author(s): Kuroda K
  • Organizer: Proc The 11th International Congress of Hyperthermic Oncology (ICHO) and The 29th Japanese Congress of Themal Medicine (JCTM) 2012;28(Suppl):p. 71
  • Place of Presentation: ハイアットリージェンシー京都（京都府）
  • Invited
• [Presentation] 磁気共鳴による非侵襲温度分布画像化：メチレン基スピン格子緩和時間による脂肪温度計測手法の最適化
  • Author(s): 森田修平, 本田真俊, 小原 真, 堀江朋彦, 今井 裕, 黒田 輝
  • Organizer: 関東ハイパーサーミア研究会
  • Place of Presentation: 東京厚生年金病院（東京都）
• [Book] Temperature Monitoring by Chemical Shift-Based Method, in Handbook of in vivo Magnetic Resonance Spectroscopy (2015)
  • Author(s): Kuroda K
  • Total Pages: 12
  • Publisher: John Wiley & Sons, Ltd
• [Remarks] BMEiCON2013 Keynote Speakers
  • URL: http://www.bmeicon.org/download/CV_kuroda.pdf