| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In order to execute high intensity focused ultrasound (HIFU) therapy for breast and bone marrow safely and effectively, we planned to establish a noninvasive and quantitative temperature imaging technique using spin-lattice relaxation time (T1) of proton of methylene chain observed by magnetic resonance imaging (MRI). Based on a new finding that the signal intensity ratio of the chemical shift components of fatty acid in bovine and porcine tissues is insensitive to temperature, we have proposed a novel T1 estimation technique using the ratio among the nine fat signal components as a prior knowledge in the image processing following multiple-point Dixon and multiple flip angle imaging. The usefulness and robustness of the technique was demonstrated with numerical simulation.
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