| Project/Area Number |
24500521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUI Hiroshi 大阪工業大学, 工学部, 教授 (00351453)
NAKAMURA Tomohiro 大阪工業大学, 工学部, 准教授 (30217872)
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| Research Collaborator |
SAWADA Kazuya
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 組織工学 / 培養骨格筋 / 電気刺激 / スキャフォールド / コラーゲン / スポンジ / アクチュエータ / ケラチン |
|---|
| Outline of Final Research Achievements |
Tissue-engineered skeletal muscle for a soft actuator was investigated in three points of thickening and elongation, bend and stretch structure, and longtime application. For thickening and elongation, a collagen sponge scaffold having angiostructure was newly developed and seeded myoblasts inside were cultured by circulation bioreactor. For bend and stretch structure, controlled electric field stimulation could be applied to tissue-engineered muscle by parallel electrodes. For longtime application, circulation bioreactor could maintain the tissue-engineered muscle for more than one month.
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