| Project/Area Number |
24500522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kinki University |
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Principal Investigator |
YAMAMOTO Ei 近畿大学, 生物理工学部, 准教授 (00309270)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | バイオメカニクス / 微小損傷 / 損傷治癒 / 力学的特性 / 生体硬組織 / 生体軟組織 / 骨 / 皮膚 / 血管 / マイクロダメージ / リモデリング / 恒常性 |
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| Outline of Final Research Achievements |
Microdamage in load-bearing biological tissues is an important factor related to their homeostatic responses and diseases. However, there have been only a few reports on the microdamages not only in hard tissues such as bones but also in soft tissues such as blood vessels, tendons, and skins. In the present study, changes in the mechanical properties of osteoporotic bones, ultraviolet-irradiated skins, and hypertensive arteries were elucidated by means of compressive, tensile, or internal pressure tests. It was speculated that the decreases in the mechanical strength were linked to the microdamages in the tissues. We have an insight into the mechanisms of homeostatic responses and healing process in biological tissues.
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