The application to cancer vaccine of SSF that mimics pulmonary surfactant

• Project/Area Number: 24500527
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Musashino University (2013-2014); The University of Tokushima (2012)
• Principal Investigator: MIZUNO Dai 武蔵野大学, 薬学研究所, 講師 (70380061)
• Co-Investigator(Renkei-kenkyūsha): KIDO Hiroshi 徳島大学, 疾患酵素学研究センター, 特任教授 (50144978)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肺サーファクタント / 粘膜免疫 / ワクチン / 生体機能材料 / 抗原デリバリー

Outline of Final Research Achievements

The cellular immunity inducing effect of SSF, a synthetic adjuvant that mimics pulmonary surfactant, were shown in this study. Nasal inoculation of vaccine and SSF induced IgG2a antibody, IFN-γ secreting T cell, and cytotoxic T cell. SSF is assumed to be a mucosal adjuvant that useful for cancer vaccine therapy.

Research Products

• [Journal Article] Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia. (2015)
  • Author(s): Mizuno D et al
  • Journal Title: Metallomics Volume: 印刷中 Issue: 8 Pages: 1-7
  • DOI: 10.1039/c5mt00049a
  • Peer Reviewed
• [Journal Article] Oral Administration of Lactobacillus pentosus Strain S-PT84 Enhances Anti-Influenza Virus-Specific IgG Production in Plasma after Limited Dose of Influenza Virus Vaccination in Mice. (2015)
  • Author(s): Maekawa T et al.
  • Journal Title: J Vac Immunotechnol Volume: 2 Pages: 1-5
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of trace elements in the pathogenesis of prion diseases. (2014)
  • Author(s): Mizuno D et al.
  • Journal Title: Curr Pharm Biotech Volume: 15 Issue: 11 Pages: 1049-1057
  • DOI: 10.2174/1389201015666141103020625
  • Peer Reviewed / Open Access
• [Journal Article] Carnosine: A Possible Drug for Vascular Dementia. (2014)
  • Author(s): Mizuno D et al.
  • Journal Title: J Vasc Med Surg Volume: 2 Issue: 03 Pages: 146-146
  • DOI: 10.4172/2329-6925.1000146
  • Peer Reviewed / Open Access
• [Journal Article] Disruption of zinc homeostasis and the pathogenesis of senile dementia (2014)
  • Author(s): M. Kawahara, D. Mizuno, H. Koyama, K. Konoha, S. Ohkawara, Y. Sadakane
  • Journal Title: Metallomics Volume: 6 Issue: 2 Pages: 209-216
  • DOI: 10.1039/c3mt00257h
  • Peer Reviewed
• [Journal Article] Immunomodulator clarithromycin enhamces mucosal and systemic immune responses and reduces re-infection rate in pediatric patients with influenza treated with antiviral neuraminidase inhibitor: A retrospective analysis. (2013)
  • Author(s): Wakako Shinahara, Etsuhisa Takahashi, Takako Sawabuchi, Masaru Arai, Nobuo Hirotsu, Yoshio Takasaki, Shizuo Shindo, Kyoko Shibao, Takashi Yokoyama, Kiyoshi Nishikawa, Masahiro Mino, Minako Iwaya, Yuji Yamashita, Satoshi Suzuki, Dai Mizuno, Hiroshi Kido
  • Journal Title: PLoS ONE Volume: 8(7) Issue: 7 Pages: e70060-e70060
  • DOI: 10.1371/journal.pone.0070060
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The involvement of endoplasmic reticulum-stress in zinc neurotoxicity and the pathogenesis of vascular type senile dementia. (2013)
  • Author(s): Mizuno D et al.
  • Journal Title: Int J Mol Sci Volume: 14 Issue: 11 Pages: 22067-22081
  • DOI: 10.3390/ijms141122067
  • Peer Reviewed
• [Journal Article] Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF-10 –Induction of potent local and systemic immunity with balanced Th1 and Th2 responses (2013)
  • Author(s): Takashi Kimoto 他
  • Journal Title: Influenza Other Respir. Viruses Volume: 7(6) Issue: 6 Pages: 1218-1226
  • DOI: 10.1111/irv.12124
  • Peer Reviewed / Open Access
• [Journal Article] Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus. (2012)
  • Author(s): Takahashi E et al.
  • Journal Title: J Virol. Volume: 86 Issue: 20 Pages: 10924-10934
  • DOI: 10.1128/jvi.01207-12
  • Peer Reviewed
• [Journal Article] マクロライド薬によるインフルエンザ感染時の粘膜免疫増強作用 (2012)
  • Author(s): 木戸 博 他
  • Journal Title: 臨床と微生物 Volume: 39 Pages: 331-335
• [Presentation] 日本の予防接種制度を、予防接種禍から考える (2014)
  • Author(s): 水野 大
  • Organizer: 日本社会医療学会第15回記念大会
  • Place of Presentation: 九州保健福祉大学(宮崎)
  • Year and Date: 2014-10-18 – 2014-10-19
• [Presentation] アロマテラピー精油in vitro 機能評価系の開発, (2014)
  • Author(s): 水野 大 他
  • Organizer: 第27回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 帝京大学(東京)
  • Year and Date: 2014-08-20 – 2014-08-21
• [Presentation] アロマテラピー精油のGT1-7細胞 (不死化視床下部神経細胞) に対する影響 (2014)
  • Author(s): 水野 大 他
  • Organizer: 第134回日本薬学会年会
  • Place of Presentation: 熊本市総合体育館（熊本）
• [Presentation] 脳血管認知症予防・治療薬としてのカルノシンの作用メカニズム解析 (2014)
  • Author(s): 水野 大 他
  • Organizer: 第134回日本薬学会年会
  • Place of Presentation: 熊本市総合体育館（熊本）
• [Presentation] Effects of carnosine on Zinc-induced neurotoxicity and its analysis in rat’s brain (2013)
  • Author(s): Mizuno D et al.
  • Organizer: International Society For Trance Element Reserch in Humans 2013
  • Place of Presentation: Keio Plaza Hotel (Tokyo)
• [Presentation] 人工サーファクタントSF10による経鼻インフルエンザワクチンアジュバント効果 (2013)
  • Author(s): 水野 大 他
  • Organizer: 第57回日本薬学会関東支部大会
  • Place of Presentation: 帝京大学板橋キャンパス（東京）
• [Presentation] 亜鉛による神経細胞死のカルノシン抑制機構の検討 (2013)
  • Author(s): 水野 大 他
  • Organizer: 第26回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 昭和大学旗の台キャンパス（東京）
• [Presentation] カニクイザルを用いた、ヒト肺サーファクタント由来SF-10アジュバントによる経鼻インフルエンザワクチンの効果検討 (2012)
  • Author(s): 水野 大 他
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] カニクイザルを用いた、ヒト肺サーファクタント由来SF-10アジュバントによる経鼻インフルエンザワクチンの効果検討 (2012)
  • Author(s): 水野 大 他
  • Organizer: 第16回日本ワクチン学会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
• [Book] 18．薬事制度（医薬品・医療機器等の恩恵と被害）. 『生命倫理・医事法』 (分担著) (2015)
  • Author(s): 水野 大 他
  • Publisher: 医療科学社
• [Book] Oligomerization of Chemical and Biological Compounds. (ISBN 980-953-307-1130-3) (2014)
  • Author(s): Mizuno D and Kawahara M
  • Publisher: Lesieur C, InTech
• [Book] ワクチン開発における最新動向～規制動向・安全性評価・品質管理・アジュバント・開発事例～( ISBN 980-953-307-1130-3) (2013)
  • Author(s): 水野 大 他
  • Total Pages: 220
  • Publisher: 株式会社情報機構