Preparation of polyphosphoesters for controlled bone remodeling
| Project/Area Number |
24500532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kansai University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ポリリン酸エステル / 開環重合 / 骨リモデリング / 骨芽細胞 / 破骨細胞 / DDS / プロドラッグ / 骨疾患 / タンパク質 / バイオコンジュゲーション / プロドラック |
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| Outline of Final Research Achievements |
Polyphosphoesters are unique polymeric biomaterials because of their biocompatibility, biodegradability and bone affinity. Synthesis of poly(ethylene sodium phosphate) (PEP-Na) was achieved through ring-opening polymerization of 2-methoxy-2-oxo-1,3,2-dioxaphospholane followed by hydrolysis. We investigated the viability and function of human osteoclasts and murine osteoblasts precursors in contact with 100 mg/mL of PEP-Na This did not trigger any significant effect on osteoblast cell viability. In contrast, the polymer effectively reduced the adhesion of human osteoclasts on bone slices at concentration as low as 0.0001 mg/mL. Moreover, the in situ generation of resorption pits was also effectively reduced. This is the first report to demonstrate the possibility of using polyphosphoesters for selective inhibition of osteoclast function and bone resorption. This study indicates that PEP-Na has potential to be used as an effective polymer prodrug for bone therapy.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] 骨親和性酵素複合体の調製2014
Author(s)
徳永昌啓、岩﨑泰彦、原田敦史
Organizer
日本バイオマテリアル学会第９回関西若手研究発表会
Place of Presentation
京都大学、京都
Year and Date
2014-08-05
Related Report
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