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Preparation of polyphosphoesters for controlled bone remodeling

Research Project

Project/Area Number 24500532
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKansai University

Principal Investigator

IWASAKI Yasuhiko  関西大学, 化学生命工学部, 教授 (90280990)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsポリリン酸エステル / 開環重合 / 骨リモデリング / 骨芽細胞 / 破骨細胞 / DDS / プロドラッグ / 骨疾患 / タンパク質 / バイオコンジュゲーション / プロドラック
Outline of Final Research Achievements

Polyphosphoesters are unique polymeric biomaterials because of their biocompatibility, biodegradability and bone affinity. Synthesis of poly(ethylene sodium phosphate) (PEP-Na) was achieved through ring-opening polymerization of 2-methoxy-2-oxo-1,3,2-dioxaphospholane followed by hydrolysis. We investigated the viability and function of human osteoclasts and murine osteoblasts precursors in contact with 100 mg/mL of PEP-Na This did not trigger any significant effect on osteoblast cell viability. In contrast, the polymer effectively reduced the adhesion of human osteoclasts on bone slices at concentration as low as 0.0001 mg/mL. Moreover, the in situ generation of resorption pits was also effectively reduced. This is the first report to demonstrate the possibility of using polyphosphoesters for selective inhibition of osteoclast function and bone resorption. This study indicates that PEP-Na has potential to be used as an effective polymer prodrug for bone therapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Invited: 3 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Self-setting particle-stabilized emulsion for hard-tissue engineering2015

    • Author(s)
      Y. Iwasaki, Y. Takahata, S. Fujii
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 126 Pages: 394-400

    • DOI

      10.1016/j.colsurfb.2014.12.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] リン酸エステル結合を主鎖にもつポリマーの制御合成と薬物輸送担体への応用2014

    • Author(s)
      岩﨑泰彦
    • Journal Title

      日本ゴム協会誌

      Volume: 87 Pages: 411-415

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Spontaneous assembly into pseudopolyrotaxane between cyclodextrins and biodegradable polyphosphoester ionomers2014

    • Author(s)
      Atsushi Tamura, Masahiro Tokunaga, Yasuhiko Iwasaki, Nobuhiko Yui
    • Journal Title

      Macromolecular Chemistry and Physics

      Volume: 215 Issue: 7 Pages: 648-653

    • DOI

      10.1002/macp.201300774

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 核酸の構造に倣ったポリマーバイオマテリアル2013

    • Author(s)
      岩﨑泰彦
    • Journal Title

      機能材料

      Volume: 33 Pages: 48-54

    • Related Report
      2013 Research-status Report
  • [Journal Article] Comparative physicochemical properties and cytotoxicity of polyphosphoester ionomers with bisphosphonates2013

    • Author(s)
      Iwasaki Y, Katayama K, Yoshida M, Yamamoto M, Tabata Y
    • Journal Title

      Journal of Biomaterials Science, Polymer Edition

      Volume: 24 Issue: 7 Pages: 882-895

    • DOI

      10.1080/09205063.2012.710823

    • Related Report
      2012 Research-status Report
  • [Journal Article] Synthesis of amphiphilic polyphosphoester ionomers for surface modification of small unilamellar phospholipid vesicles2012

    • Author(s)
      Ikeuchi R, Iwasaki Y
    • Journal Title

      Trans. Mater. Res. Soc. Jpn.

      Volume: 37 Pages: 365-368

    • NAID

      130004676405

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 硬組織親和性を示すポリマー/酵素複合体の調製2014

    • Author(s)
      徳永昌啓、岩﨑泰彦、原田敦史
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨親和性酵素複合体の調製2014

    • Author(s)
      徳永昌啓、岩﨑泰彦、原田敦史
    • Organizer
      日本バイオマテリアル学会第9回関西若手研究発表会
    • Place of Presentation
      京都大学、京都
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリリン酸エステルを修飾したリゾチームの溶菌活性2014

    • Author(s)
      徳永昌啓、岩﨑泰彦
    • Organizer
      第43回医用高分子シンポジウム
    • Place of Presentation
      産総研:臨海副都心センター、東京
    • Year and Date
      2014-07-28 – 2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Polyphosphoester-based biomaterials2014

    • Author(s)
      Yasuhiko Iwasaki
    • Organizer
      Macro2014
    • Place of Presentation
      Chiang Mai International Convention and Exhibition Center, Thailand
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 無機/有機混合微粒子からなる自己硬化型エマルションの創製2013

    • Author(s)
      高畑祐輔,岩崎泰彦,藤井秀司
    • Organizer
      第62回高分子学会年次大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリリン酸エステルアイオノマーとタンパク質の複合化2013

    • Author(s)
      徳永昌啓,岩崎泰彦
    • Organizer
      第62回高分子学会年次大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 無機/有機微粒子を用いた多孔質構造を形成する新規骨ペーストの開発2013

    • Author(s)
      高畑祐輔, 岩﨑泰彦,藤井秀司
    • Organizer
      第59回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリリン酸エステルアイオノマーと複合化したタンパク質の特能2013

    • Author(s)
      徳永昌啓,岩崎泰彦,原田敦史
    • Organizer
      第59回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 連通多孔質硬化体を自発的に形成する無機/有機微粒子安定化エマルション2013

    • Author(s)
      高畑祐輔, 岩﨑泰彦,藤井秀司
    • Organizer
      第8回日本バイオマテリアル学会関西若手研究発表会
    • Place of Presentation
      大阪大学銀杏会館
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリリン酸エステルアイオノマー修飾タンパク質の調製と機能2013

    • Author(s)
      徳永昌啓,岩崎泰彦,原田敦史
    • Organizer
      ポリリン酸エステルアイオノマー修飾タンパク質の調製と機能
    • Place of Presentation
      金沢大学(石川)
    • Related Report
      2013 Research-status Report
  • [Presentation] 硬組織補修を指向した自己硬化型微粒子安定化エマルション2013

    • Author(s)
      高畑祐輔, 岩﨑泰彦,藤井秀司
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリリン酸エステルの制御合成とバイオマテリアルとしての利用2012

    • Author(s)
      岩崎泰彦
    • Organizer
      第61回高分子年次大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Imparting mineral affinity to liposomes by ionized polyphosphoester immobilization2012

    • Author(s)
      Iwasaki Y, Ikeuchi R
    • Organizer
      9th World Biomaterials Congress
    • Place of Presentation
      Chengdu
    • Related Report
      2012 Research-status Report
  • [Presentation] ピッカリングエマルションを鋳型とした無機/有機複合多孔質体の調製2012

    • Author(s)
      高畑祐輔, 岩崎泰彦,藤井秀司
    • Organizer
      第58回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体に倣ったリン含有ポリマーバイオマテリアルの設計2012

    • Author(s)
      岩崎泰彦
    • Organizer
      プラスチック技術者協会の定例講演会
    • Place of Presentation
      住友ベークライト本社会議室
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 微粒子安定化エマルションをテンプレートとした自己硬化型骨補填材の創製2012

    • Author(s)
      高畑祐輔, 岩崎泰彦, 藤井秀司
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Research-status Report
  • [Book] 伝子医学MOOK 別冊 細胞の3次元組織化-その最先端技術と材料技術. (田畑泰彦 編集)2014

    • Author(s)
      岩﨑泰彦
    • Total Pages
      363
    • Publisher
      メディカルドゥ
    • Related Report
      2014 Annual Research Report
  • [Book] 先端バイオマテリアルハンドブック2012

    • Author(s)
      岩崎泰彦(共著)
    • Total Pages
      580
    • Publisher
      リン原子含有ポリマーのバイオマテリアルへの応用
    • Related Report
      2012 Research-status Report
  • [Remarks] 関西大学 化学生命工学部 化学・物質工学科 生体材料学研究室

    • URL

      http://www.chemmater.kansai-u.ac.jp/biomat/

    • Related Report
      2013 Research-status Report
  • [Remarks] 関西大学 化学生命工学部 生体材料学研究室

    • URL

      http://www.chemmater.kansai-u.ac.jp/biomat/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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