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Study on the next generation stent construction for cerebral aneurysm

Research Project

Project/Area Number 24500535
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionTsuruoka National College of Technology (2014)
Tohoku University (2012-2013)

Principal Investigator

NAKAYAMA Toshio  鶴岡工業高等専門学校, その他部局等, その他 (80451631)

Co-Investigator(Kenkyū-buntansha) OHTA Makoto  東北大学, 流体科学研究所, 准教授 (20400418)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords流体力学 / 数値流体力学解析 / ステント / 脳動脈瘤 / 最適化 / 生体内流れ / 流体工学
Outline of Final Research Achievements

In this study, the purpose is the development method construction of the next generation stent for cerebral aneurysm. First, the classification method of cerebral aneurysm based on fluid dynamics using consideration curvature of the parent artery in addition to Aspect Ratio was developed. Therefore, it becomes possible to design of the effective stent using this classification method. The fluid-structural interaction analysis was introduced in the development of stent design method. The vessel wall and cerebral aneurysm wall are varied due to the influence of the blood flow. The simulation accuracy is higher than conventional numerical fluid dynamics analysis and it is possible to develop the stent adapting for cerebral aneurysm. From study results, it is possible to find the development method construction of next generation stent.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (14 results) (of which Invited: 6 results)

  • [Journal Article] Investigation of characteristic hemodynamic parameters indicating thinning and thickening sites of cerebral aneurysms2015

    • Author(s)
      Daichi SUZUKI, Kenichi FUNAMOTO, Shinichiro SUGIYAMA, Toshio NAKAYAMA, Toshiyuki HAYASE, Teiji TOMINAGA
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 10 Issue: 1 Pages: 14-00265-14-00265

    • DOI

      10.1299/jbse.14-00265

    • NAID

      130005068594

    • ISSN
      1880-9863
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relative Residence Time Prolongation in Intracranial Aneurysms: A Possible Association With Atherosclerosis2013

    • Author(s)
      Sugiyama S, Niizuma K, Nakayama T, Shimizu H, Endo H, Inoue T, Fujimura M, Ohta M, Takahashi A, Tominaga T.
    • Journal Title

      Neurosurgery

      Volume: 73(5) Pages: 767-776

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Classification of Blood Flow in Cerebral Aneurysm Considering the Parent Artery2013

    • Author(s)
      oshio Nakayama, Shin-ichiro Sugiyama, Makoto Ohta
    • Journal Title

      ASME 2013 International Mechanical Engineering Congress and Exposition

      Volume: 3A

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Observation of the expansion behavior and quantitative evaluation of elastic recoil of a balloon-expandable stent in three dimensions using a Micro-CT system2012

    • Author(s)
      Mori F, Nakayama T, Matsuzawa T, Ohta M.
    • Journal Title

      Technol Health Care.

      Volume: 20(4) Pages: 305-315

    • NAID

      120005327140

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Blood flow analysis in cerebral aneurysm and around stent using CFD2014

    • Author(s)
      Toshio Nakayama, Makoto Ohta
    • Organizer
      1st International symposium for collaborative research between Tohoku University and Technische Universitaet Braunschweig
    • Place of Presentation
      ドイツ
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A Comparison of Experimental and CFD Analyses for Permeability of Cancellous Bone2014

    • Author(s)
      Wataru Sakuma, Toshio Nakayama, Hitomi Anzai, Makoto Ohta
    • Organizer
      1st International symposium for collaborative research between Tohoku University and Technische Universitaet Braunschweig
    • Place of Presentation
      ドイツ
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Classification of flow pattern in neck based considering the parent artery curves and stent implantation2013

    • Author(s)
      Toshio Nakayama, Makoto Ohta
    • Organizer
      ICS 2013
    • Place of Presentation
      Argentina, Buenos Aires
    • Related Report
      2013 Research-status Report
  • [Presentation] Stagnant Blood Flow in Intracranial Aneurysms: A Possible Association with Atherosclerosis2013

    • Author(s)
      Shin-ichiro Sugiyama, Toshio Nakayama, Kenichi Funamoto, Daichi Suzuki, Kuniyasu Niizuma, Makoto Ohta, Teiji Tominaga
    • Organizer
      The 10th ICFD
    • Place of Presentation
      Japan, Sendai
    • Related Report
      2013 Research-status Report
  • [Presentation] Hemodynamic Numerical Simulation in Artery Complicated with both Stenosis and Aneurysm in Different Shape and Position2013

    • Author(s)
      Y.J.Li, H.Anzai, T.Nakayama, Y.Shimizu, Y.Miura, A.K.Qiao M.Ohta
    • Organizer
      The 5th Asia Pacific Congress on Computational Mechanics (APCOM2013)
    • Place of Presentation
      Singapore, Singapore
    • Related Report
      2013 Research-status Report
  • [Presentation] Optimized Stent2013

    • Author(s)
      Makoto Ohta. Hitomi Anzai, Toshio Nakayama, Xiaobo Han, Noriko Tomita
    • Organizer
      The 10th ICFD
    • Place of Presentation
      Japan, Sendai
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 親血管形状による動脈瘤の分類に対するステントストラットパターンの最適化に関する研究2013

    • Author(s)
      中山 敏男, 郭 信圭, Srinivas Karkenahalli, 太田 信
    • Organizer
      第25回 バイオエンジニアリング講演会
    • Place of Presentation
      つくば,茨城
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of the Aspect Ratio of Cerebral Aneurysms on Blood Flow Reduction after Optimized Stent Placement2012

    • Author(s)
      Toshio Nakayama, Shinkyu Jeong, Karkenahalli Srinivas, Makoto Ohta
    • Organizer
      Ninth International Conference on Flow Dynamic
    • Place of Presentation
      Miyagi, Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Development of stent for cerebral aneurysm using fluid dynamics2012

    • Author(s)
      Toshio Nakayama, Makoto Ohta
    • Organizer
      2012 Beijing International Symposium on Biomechanics
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Flow analysis of stenosis and aneurysm using hydrogel for comparison to computational simulation2012

    • Author(s)
      Makoto Ohta, Toshio Nakayama, Hitomi Anzai
    • Organizer
      GRADUATE SEMINAR SPONSORED BY: MECHANICAL ENGINEERING and MATERIALS SCIENCE
    • Place of Presentation
      Pittsburgh, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Classification of Flow Pattern in Neck Based on Parent Artery Configuration and Optimized Stent Implantation2012

    • Author(s)
      Toshio Nakayama, Shinkyu Jeong, Makoto Ohta, Karkenahalli Srinivas
    • Organizer
      The 9th Intracranial Stent Meeting (ICS12)
    • Place of Presentation
      Madison, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] ステントストラットパターンの最適化を持ちたステント開発に関する研究2012

    • Author(s)
      中山 敏男,郭 信圭,Karkenahalli SRINIVAS, 太田 信
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢,石川
    • Related Report
      2012 Research-status Report
  • [Presentation] 医療デバイス周りの血流流体力学的見地からの血栓形成2012

    • Author(s)
      太田 信,S. Wetzel,安西 眸,中山 敏男,韓 笑波,清水 康智,小澤 桂,冨田 典子
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台,宮城
    • Related Report
      2012 Research-status Report
  • [Presentation] Modeling Flow Diverter Stent using Porous Media2012

    • Author(s)
      Makoto Ohta, Yukihisa Miura, Hitomi Anzai, Toshio Nakayama
    • Organizer
      The 9th Intracranial Stent Meeting (ICS12)
    • Place of Presentation
      Madison, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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