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Automated detection and tracking of abnormal regions on FDG-PET images

Research Project

Project/Area Number 24500543
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionGifu University

Principal Investigator

HARA Takeshi  岐阜大学, 医学(系)研究科(研究院), 准教授 (10283285)

Co-Investigator(Kenkyū-buntansha) KATAFUCHI Tetsuro  岐阜医療科学大学, 保健科学部, 教授 (00393231)
FUJITA Hiroshi  岐阜大学, 医学系研究科, 教授 (10124033)
Co-Investigator(Renkei-kenkyūsha) ITO Satoshi  大雄会総合病院, 放射線科, 医長
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords核医学 / FDG-PET / コンピュータ支援診断 / 化学療法 / コンピュータ支援診断システム / 観察者実験 / PET/CT / 体幹部 / 解剖学的標準化
Outline of Final Research Achievements

We have developed a prototype of computer-aided diagnosis system for FDG-PET images based on statistical image analysis. Fifty-five cases were employed to evaluate the initial performance. As a result of this work, we have achieved 95% true-positive fraction to detect abnormal spots and to track the activity changes between two time series examinations. The evaluation of activity changes of 76% examinations showed the same results as radiologists' comments.
In conclusions, the presentation of activity changes with SUV and Z-score will be a helpful index for the interpretation of FDG-PET images during the cancer treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013 2012 Other

All Journal Article (12 results) (of which Acknowledgement Compliant: 2 results,  Peer Reviewed: 3 results) Presentation (12 results) (of which Invited: 3 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 体幹部 FDG-PET/CT画像における統計画像解析法の基礎検討2014

    • Author(s)
      清水美帆,原 武史,周 向栄,村松千左子,伊藤 哲,汲田伸一郎,石原圭一,片渕哲朗,藤田広志
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 114 Pages: 39-42

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 体幹部FDG-PET画像における除脂肪体重を用いた正常モデルの構築と解析2014

    • Author(s)
      清水勇介,原 武史,福岡大輔,周 向栄,村松千左子,伊藤哲,箱崎謙太,汲田伸一郎,石原圭一,片渕哲朗,藤田広志
    • Journal Title

      電子情報通信学会技術報告

      Volume: 113 Pages: 97-101

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Temporal subtraction system on torso FDG-PET scans based on statistical image analysis2013

    • Author(s)
      Y.Shimizu, T. Hara, D. Fukuoka, X.Zhou, C.Muramatsu, S.Ito, K.Hakozaki, S.Kumita, K.Ishihara, T.Katafuchi, H.Fujita
    • Journal Title

      Proc. of SPIE Medical Imaging 2013

      Volume: 8670

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Particle system based adaptive sampling on spherical parameter space to improve the MDL method for construction of statistical shape models2013

    • Author(s)
      R.Xu, X.Zhou, Y.Hirano, R.Tachibana, T.Hara, S.Kido, and H.Fujita
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: 2013年度 Pages: 196259-196268

    • DOI

      10.1155/2013/196259

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 症例の類似性を考慮した複数臓器確率的アトラス構築と評価2013

    • Author(s)
      渡辺篤人,周 向栄,陳 華岳,原 武史,横山龍二郎,兼松雅之,星 博昭,藤田広志
    • Journal Title

      電子情報通信学会技術報告

      Volume: MI2013 Pages: 77-81

    • Related Report
      2013 Research-status Report
  • [Journal Article] An automatic detection method for carotid artery calcifications using top-hat filter on dental panoramic radiographs2013

    • Author(s)
      T.Sawagashira, T.Hayashi, T.Hara, A.Katsumata, C.Muramatsu, X.Zhou, Y.Iida, K.Katagi, and H.Fujita
    • Journal Title

      IEICE Transactions on Information and Systems

      Volume: E96-D (8) Pages: 1878-1881

    • NAID

      130003370972

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 頭頸部領域におけるコンピュータ支援診断システムの開発と現状2013

    • Author(s)
      福岡大輔,内山良一,村松千左子,原 武史,藤田広志
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 69 Pages: 1313-1319

    • NAID

      10031203908

    • Related Report
      2013 Research-status Report
  • [Journal Article] 体幹部FDG-PET画像の解剖学的自動位置合わせ手法精度評価2012

    • Author(s)
      清水勇介,鈴木祈史,小林龍徳,原 武史,周 向栄,伊藤 哲,汲田伸一郎,石原圭一,片渕哲朗,藤田広志
    • Journal Title

      電子情報通信学会技術報告

      Volume: 111 Pages: 7-10

    • Related Report
      2012 Research-status Report
  • [Journal Article] 体幹部FDG-PET画像における正常SUV分布モデルの構築と経時変化の解析2012

    • Author(s)
      鈴木祈史,清水勇介,小林龍徳,原 武史,周 向栄,伊藤 哲,片渕哲朗,藤田広志
    • Journal Title

      電子情報通信学会技術報告

      Volume: 111 Pages: 281-286

    • NAID

      10031093536

    • Related Report
      2012 Research-status Report
  • [Journal Article] 非造影CT画像からの類似検索による臓器自動抽出法の検討, 電子情報通信学会技術報告2012

    • Author(s)
      渡辺篤人,周 向栄,陳 華岳,原 武史,横山龍二郎,兼松雅之,星 博昭,藤田広志
    • Journal Title

      電子情報通信学会技術報告

      Volume: 111 Pages: 407-410

    • Related Report
      2012 Research-status Report
  • [Journal Article] User-friendly tools on hand-held devices for observer performance study2012

    • Author(s)
      T.Matsumoto, T.Hara, J.Shiraishi, D.Fukuoka, H.Abe, M.Matsusako, A.Yamada, X.Zhou, and H.Fujita
    • Journal Title

      Proc. SPIE Medical Imaging

      Volume: 83181

    • Related Report
      2012 Research-status Report
  • [Journal Article] 二肢強制選択法によるステレオシンチグラムにおける集積位置の距離弁別能の測定2012

    • Author(s)
      原 武史,山崎雄章,片渕哲朗,小林龍徳,松迫正樹,村松千左子,周 向栄,藤田広志
    • Journal Title

      電子情報通信学会技術報告

      Volume: 112 Pages: 55-58

    • NAID

      110009636798

    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of automatic segmentation results of organ regions on torso CT images of FDG-PET/CT2015

    • Author(s)
      M. Shimizu, T. Hara, X. Zhou, C. Muramatsu, S. Ito, S. Kumita, K. Ishihara, T. Katafuchi, H. Fujita
    • Organizer
      2015 Joint Inference of IWIT and IFMIA
    • Place of Presentation
      台湾・Cheng Kung University
    • Year and Date
      2015-01-11 – 2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Z-score Imaging of Torso FDG-PET SUV and Computer-aided Diagnostic System based on Anatomical Standardization2014

    • Author(s)
      M. Shimizu, T. Hara, X. Zhou, C. Muramatsu, S. Ito, S. Kumita, K. Ishihara, T. Katafuchi, H. Fujita
    • Organizer
      Radiological Society of North America
    • Place of Presentation
      米国シカゴ市・マコーミックプレイス
    • Year and Date
      2014-11-29 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体幹部FDG-PET/CT画像における統計画像解析法の基礎検討2014

    • Author(s)
      清水美帆,原 武史,周 向栄,村松千佐子,伊藤 哲,汲田伸一郎,石原圭一,片渕哲朗,藤田広志
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      東京都立川市・統計数理研究所
    • Year and Date
      2014-09-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体幹部FDG-PET画像における 除脂肪体重を用いた正常モデルの構築と解析2014

    • Author(s)
      清水勇介,原 武史,福岡大輔,周 向栄,伊藤 哲,箱崎謙太,汲田伸一郎,石原圭一,片渕哲朗,藤田広志
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of temporal subtraction CAD system using statistical image analysis technique on torso FDG-PET scans2013

    • Author(s)
      河合亮輔,原 武史,片渕哲朗,汲田伸一郎,伊藤 哲,藤田広志
    • Organizer
      日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Automated detection of temporal changes on torso FDG-PET scans by using anatomical standardization approach2013

    • Author(s)
      原 武史,片渕哲朗,箱崎謙太,伊藤 哲,清水勇介,周 向栄,石原圭一,汲田伸一郎,藤田広志
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging
    • Place of Presentation
      カナダ・バンクーバー
    • Related Report
      2013 Research-status Report
  • [Presentation] 胸部X線画像との画像融合を利用した心筋シンチグラムにおける心臓縦隔 比の測定法2013

    • Author(s)
      河合亮輔,原 武史,片渕哲朗,清水勇介,周 向栄,安部美輝,村松千左子,藤田広志
    • Organizer
      日本医用画像工学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 原 武史,片渕哲朗,藤田広志2013

    • Author(s)
      核医学画像を対象とした画像診断および検査支援システムの開発
    • Organizer
      電子情報通信学会 医用画像研究会
    • Place of Presentation
      那覇市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Automated tracking system of abnormal spots on FDG-PET images for cancer treatments.2012

    • Author(s)
      Takeshi Hara, Tetsuro Katafuchi, Satoshi Ito, Yusuke Shimizu, Xiangrong Zhou, Hiroshi Fujita
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      アメリカ合衆国・マイアミビーチ市
    • Related Report
      2012 Research-status Report
  • [Presentation] コンピュータ支援診断の現状2012

    • Author(s)
      原 武史
    • Organizer
      核医学技術学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 体幹部 FDG-PET2012

    • Author(s)
      原 武史
    • Organizer
      核医学技術学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Computer assisted measurement based on automation of Patlak Plot method for mean cerebral blood flow on dynamic scintigrams

    • Author(s)
      山崎雄章,原 武史,多湖博史,福岡大輔,片渕哲朗,後藤裕夫,藤田広志
    • Organizer
      日本生体医工学会 生体医用画像研究会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Book] 医用画像ハンドブック 1.3 マンモグラフィ2012

    • Author(s)
      原 武史(分担執筆)
    • Total Pages
      800
    • Publisher
      日本医用画像工学会
    • Related Report
      2012 Research-status Report
  • [Book] 実践 医用画像解析ハンドブック2012

    • Author(s)
      藤田広志,石田隆行,桂川茂彦(監修)藤田広志,石田隆行,桂川茂彦,原 武史,目加田慶人,加野亜紀子,羽石秀昭(共編);藤田広志,原 武史,周 向栄,村松千左子,他(分担執筆)
    • Total Pages
      898
    • Publisher
      オーム社
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 放射性医薬品の異常集積の検出2012

    • Inventor(s)
      原 武史, 片渕 哲朗, 藤田 廣志, 西川 和宏
    • Industrial Property Rights Holder
      岐阜大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-02
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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