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Left atrial global longitudinal strain is useful for predicting pulmonary capillary wedge pressure in patients with heart disease

Research Project

Project/Area Number 24500551
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionKagoshima University

Principal Investigator

KISANUKI AKIRA  鹿児島大学, 医歯学域医学系, 教授 (20224917)

Co-Investigator(Kenkyū-buntansha) MINAGOE SHINICHI  独立行政法人国立病院機構鹿児島医療センター(臨床研究部), 臨床研究部, 副院長 (90190694)
KATAOKA TETSURO  独立行政法人国立病院機構鹿児島医療センター(臨床研究部), 臨床研究部, 室長 (70457662)
Co-Investigator(Renkei-kenkyūsha) TAKUMI TAKURO  
YUNOUE SHINGO  
MIZUKAMI NAOKO  
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心エコー / ストレイン法 / 左房機能 / 心エコー法 / 肺動脈楔入圧 / 心エコードプラ法 / 二次元スペックルトラッキング / 二次元スペックルトラッキング / heart failure
Outline of Final Research Achievements

In order to clarify the utility of left atrial strain (LAS) for predicting pulmonary capillary wedge pressure (PCWP), we studied 67 patients with heart disease using Doppler echocardiography. The patients were divided into 2 groups, into those with preserved left ventricular ejection fractions (LVEF) (PEF) and those with reduced LVEF (REF). The maximum LAS and late LAS were obtained using speckle-tracking Echo. Results: Several variables were significantly correlated with PCWP. E/Late-LAS and E/Max LAS were selected as predictors of PCWP in the PEF and REF groups, respectively. In the PEF group, E/Late-LAS displayed sensitivity and specificity values of 86% and 77%, respectively, for predicting a PCWP of >15 mmHg, whereas in the REF group E/Max LAS demonstrated equivalent values of 75% and 100%, respectively. In conclusion, LAS appears to provide useful information for predicting PCWP although the optimal predictive variable differs between patients with PEF and REF.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Presentation (2 results)

  • [Presentation] 左房Global Longitudinal Strainを用いた左房圧推定2015

    • Author(s)
      湯之上真吾
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 左房Global Longitudinal Strainjを用いた左房圧の推定2014

    • Author(s)
      湯ノ上真吾、木佐貫 彰、内匠拓朗、片岡哲郎、水上尚子,堀添善尚、茶圓秀人, 植屋奈美、髙﨑州亜、湯浅敏典、皆越眞一、大石 充.
    • Organizer
      第62回日本心臓病学会学術集会
    • Place of Presentation
      仙台市仙台市民会館
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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