Noninvasive assessment of left ventricular diastolic function using a Novel myocardial strain imaging index

• Project/Area Number: 24500554
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokyo
• Principal Investigator: DAIMON Masao 東京大学, 医学部附属病院, 講師 (80343094)
• Co-Investigator(Kenkyū-buntansha): KAWATA Takayuki 東京大学, 医学部附属病院, 助教 (20532526)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 超音波検査 / 血行動態 / 心不全 / 心臓超音波 / 心機能 / 医用超音波 / 超音波診断

Outline of Final Research Achievements

In this study, we aimed to determine whether global strain imaging diastolic index (SIDI) obtained using 2D speckle tracking imaging (2DSI) could be useful for assessing left ventricular (LV) diastolic function. We found that SIDI showed a stronger correlation with NT-pro BNP levels than conventional diastolic indices in hypertensive patients, and that longitudinal SIDI could predict elevated levels and rapid change of LV filling pressure in the clinical settings. Moreover, we reported that SIDI was useful for detecting coronary artery stenosis without a stress test in patients with normal LV wall motion. 2DSI was also useful for predicting the effect of resynchronizing therapy in congestive heart failure, and for assessing right ventricular (RV) function in rat models with pulmonary hypertension. SIDI derived from 2DSI might be one of promising index for assessing LV and RV function compared with conventional parameters.

Research Products

• [Journal Article] Guidelines from the Japanese Society of Echocardiography: Guidance for the management and maintenance of echocardiography equipment. (2015)
  • Author(s): Nakatani S, Akaishi M, Asanuma T, Hashimoto S, Izumi C, Iwanaga S, Kawai H, Daimon M, Toide H, Hayashida H, Yamada H.
  • Journal Title: Journal of Echocardiography Volume: 13 Issue: 1 Pages: 1-5
  • DOI: 10.1007/s12574-015-0240-x
  • Peer Reviewed
• [Journal Article] Evaluation of Right Ventricle by Speckle Tracking and Conventional Echocardiography in Rats with Right Ventricular Heart Failure. (2015)
  • Author(s): Kimura K, Daimon M, Morita H, Kawata T, Nakao T, Okano T, Lee S, Takenaka K, Nagai R, Yatomi Y, Komuro I.
  • Journal Title: International Heart Journal Volume: 未定
  • NAID: 130005070012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multicenter Investigations of the Prevalence of Abdominal Aortic Aneurysm in Elderly Japanese Patients With Hypertension (2015)
  • Author(s): Fukuda S, Watanabe H, Iwakura K, Daimon M, Ito H, Yoshikawa J.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 524-529
  • DOI: 10.1253/circj.CJ-14-0972
  • NAID: 130004927115
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Association between Mitral Valve Prolapse and Open-Angle Glaucoma. (2015)
  • Author(s): Chiang SJ, Daimon M, Wang LH, Hung MJ, Chang NC, Lin HC.
  • Journal Title: Heart Volume: 101 Issue: 8 Pages: 609-615
  • DOI: 10.1136/heartjnl-2014-306198
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Speckle Tracking Imaging for the Assessment of Cardiac Resynchronization Therapy (START) Study (2015)
  • Author(s): Maruo T, Seo Y, Yamada S, Arita T, Ishizu T, Shiga T, Dohi K, Toide H, Furugen A, Inoue K, Daimon M, Kawai H, Tsuruta H, Nishigami K, Yuda S, Ozawa T, Izumi C, Fumikura Y, Wada Y, Doi M, Okada M, Takenaka K, Aonuma K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 613-622
  • DOI: 10.1253/circj.CJ-14-0842
  • NAID: 130004927095
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] 拡張能をいかにとらえるか。 (2014)
  • Author(s): 中尾倫子、大門雅夫
  • Journal Title: 診断と治療 Volume: 103 Pages: 77-83
  • Open Access
• [Journal Article] Assessment of Elevated Levels and Rapid Changes of Left Ventricular Filling Pressure Using a Novel Global Strain Imaging Diastolic Index. (2014)
  • Author(s): Chiang SJ, Daimon M, Ishii K, Kawata T, Miyazaki S ,Hirose K, Ichikawa R, Miyauchi K, Yeh MH, Chang NC, Daida H.
  • Journal Title: Circulation Journal Volume: 78 Pages: 419-27
  • Peer Reviewed
• [Journal Article] Factors Responsible for Elevated Plasma B-type Natriuretic Peptide Levels in Severe Aortic Stenosis: Comparison between Elderly and Younger Patients. (2014)
  • Author(s): Sasaki S, Daimon M, Kawata1 T, Miyazaki S, Ichikawa R, Maruyama M, Chiang SJ, Mahara K, Watanabe H, Sumiyoshi T, Tomoike H, Daida H.
  • Journal Title: J Cardiol Volume: 未定
  • Peer Reviewed
• [Journal Article] Estimation of Right Atrial Pressure by Inferior Vena Cava Ultrasound in an Asian Population. (2014)
  • Author(s): Lee S, Daimon M, Kawata T, Kohro T, Kimura K, Nakao T, Koide D, Watanabe M, Yamazaki T, Komuro I.
  • Journal Title: Circulation Journal Volume: 78 Pages: 962-966
  • Peer Reviewed
• [Journal Article] rediction of Coronary Artery Stenosis at Rest in Patients with Normal Left Ventricular Wall Motion: Segmental Analyses Using Strain Imaging Diastolic Index. (2013)
  • Author(s): Yang B, Daimon M, Ishii K, Kawata T, Miyazaki S, Hirose K, Ichikawa R, Chiang SJ, Suzuki H, Miyauchi K, Daida H.
  • Journal Title: International Heart Journal Volume: 54 Pages: 266-272
  • Peer Reviewed
• [Journal Article] Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. (2013)
  • Author(s): Ichikawa R, Daimon M, Miyazaki T, Kawata T, Miyazaki S, Maruyama M, Chiang SJ, Suzuki H, Ito C, Sato F, Watada H, Daida H.
  • Journal Title: Cardiovascular Diabelology Volume: 12 Issue: 1 Pages: 38-38
  • DOI: 10.1186/1475-2840-12-38
  • Peer Reviewed
• [Journal Article] Prognostic value of coronary flow reserve assessed by transthoracic Doppler echocardiography on long-term outcome in asymptomatic patients with type 2 diabetes without overt coronary artery disease. (2013)
  • Author(s): Kawata T, Daimon M, Hasegawa R, Toyoda T, Sekine S, Himi T, Uchida D, Miyazaki S, Hirose K, Ichikawa R, Maruyama M, Suzuki H and Daida H.
  • Journal Title: Cardiovascular Diabelology Volume: 12 Issue: 1 Pages: 121-121
  • DOI: 10.1186/1475-2840-12-121
  • Peer Reviewed
• [Journal Article] 循環機能検査の新展開 (2013)
  • Author(s): 大門 雅夫
  • Journal Title: 日本内科学会雑誌 Volume: 102 Pages: 3160-3166
• [Journal Article] Clinical Factors Associated with Classical Symptoms of Aortic Valve Stenosis. (2013)
  • Author(s): ５２． Nishizaki Y, Daimon M, Miyazaki S, Suzuki H, Kawata T, Miyauchi K, Chiang SJ, Makinae H, Shinozaki T, and Daida H.
  • Journal Title: Journal of Heart Valvular Disease Volume: 未定
  • Peer Reviewed
• [Journal Article] Prediction of Coronary Artery Stenosis at Rest in Patients with Normal Left Ventricular Wall Motion: Segmental Analyses Using Strain Imaging Diastolic Index. (2013)
  • Author(s): ５４． Yang B, Daimon M, Ishii K, Kawata T, Miyazaki S, Hirose K, Ichikawa R, Chiang SJ, Suzuki H, Miyauchi K, Daida H.
  • Journal Title: International Heart Journal Volume: 未定
  • Peer Reviewed
• [Journal Article] A novel global strain diastolic index correlates with plasma NT-proBNP levels in asymptomatic hypertensive patients with preserved left ventricular ejection fraction. (2012)
  • Author(s): Chiang SJ, Daimon M, Ishii K, Miyazaki S, Koiso Y, Suzuki H, Miyauchi K, Bei Y, Yeh MH, Hwang B, Daida H.
  • Journal Title: Journal of Echocardiography Volume: 10 Issue: 2 Pages: 56-64
  • DOI: 10.1007/s12574-012-0122-4
  • Peer Reviewed
• [Presentation] Influence of early menopause on left ventricular diastolic dysfunction: A clinical observational study in healthy subjects. (2015)
  • Author(s): Hirokawa M, Daimon M, Kawata T, Nakao T, Lee S, Yatomi Y, Komuro I.
  • Organizer: 第79回日本循環器病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] 加齢に伴う心エコー図指標の変化について (2015)
  • Author(s): 大門雅夫、川田貴之、中尾倫子、木村公一、李政哲、廣川愛美、宇野漢成、竹中克
  • Organizer: 第16回心筋会
  • Place of Presentation: 東京
  • Year and Date: 2015-01-31
• [Presentation] Multi-center investigations for prevalence of abdominal aortic aneurysm in elderly Japanese patients with hypertension using pocket-sized echocardiography - AAA Japan Study - (2014)
  • Author(s): Oe H, Fukuda S, Watanabe H, Iwakura K, Daimon M, Yoshikawa J, Ito H
  • Organizer: European Society of Cardiology Congress 2013
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-31 – 2014-09-04
• [Presentation] Coronary microvascular function independently associates with left ventricular filling pressure in patients with type 2 diabetes mellitus. (2014)
  • Author(s): Kawata T, Daimon M, Ichikawa R, Maruyama M, Daida H
  • Organizer: American Society of Echocardiography 25th Annual Scientific Sessions,
  • Place of Presentation: Portland, U.S.A
  • Year and Date: 2014-06-20 – 2014-06-24
• [Presentation] 心不全を心エコー図で診る (2014)
  • Author(s): 大門雅夫
  • Organizer: 日本心臓病学会第46回教育セミナ－
  • Place of Presentation: 東京
  • Year and Date: 2014-06-01
  • Invited
• [Presentation] EFの一歩先行く心機能評価 (2014)
  • Author(s): 大門雅夫
  • Organizer: 第51回 岐阜ドプラ・心エコー研究会
  • Place of Presentation: 岐阜
  • Year and Date: 2014-05-31
  • Invited
• [Presentation] ラット病態モデルにおける高フレームレートスペックルトラッキング法の再現性 (2014)
  • Author(s): 岡野智子 木村公一 大門雅夫 中尾倫子 川田貴之 森田啓行 小室一成 矢冨裕
  • Organizer: 日本超音波医学会第87回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] 拡張型心筋症における右心機能不全 (2014)
  • Author(s): 川田 貴之、大門 雅夫、木村 公一、中尾 倫子、宇野 漢成、竹中 克、渡辺 昌文、矢冨 裕、小室 一成
  • Organizer: 第25回日本心エコー図学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] 肥満が日本人健常高齢女性の心機能に与える影響 (2014)
  • Author(s): 中尾 倫子、大門 雅夫、川田 貴之、木村 公一、宇野 漢成、山崎 力、竹中 克、矢冨 裕、小室 一成
  • Organizer: 第25回日本心エコー図学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] 肺高血圧モデルラットにおける右室ストレインイメージングの有用性 (2014)
  • Author(s): 岡野 智子、木村 公一、大門 雅夫、中尾 倫子、川田 貴之、宇野 漢成、竹中 克、森田 啓行、小室 一成、矢冨 裕
  • Organizer: 第25回日本心エコー図学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] Estimation of Right Atrial Pressure by Inferior Vena Cava Ultrasound in an Asian Population (2014)
  • Author(s): Lee SL, Daimon M, Kawata T, Kohro T, Kimura K, Nakao T, Koide D, Watanabe M, Yamazaki T, Komuro I
  • Organizer: 第78回日本循環器病学会学術集会
  • Place of Presentation: 東京
• [Presentation] Impact of Lifestyle on Left Ventricular Structure and Function in Healthy Subjects (2014)
  • Author(s): Nakao T, Daimon M, Kawata K, Kimura K, Ohzeki A, Sawaki D, Mizizuno Y, Suzuki T, Watanabe M, KomuroI , Yamazaki T.
  • Organizer: 第78回日本循環器病学会学術集会
  • Place of Presentation: 東京
• [Presentation] Prognostic Impact of Left Ventricular Noncompaction in patients with Dystrophinopathy: A Multicenter Prospective Cohort Study (2014)
  • Author(s): Kimura K, Daimon M, Nakao T, Kawata T, Nakajima T, Mikata T, Terashima M, Morita H, Komuro I.
  • Organizer: 第78回日本循環器病学会学術集会
  • Place of Presentation: 東京
• [Presentation] Heart Failure with Preserved Ejection Fraction: Diagnosis and Treatment (2014)
  • Author(s): 大門 雅夫
  • Organizer: 第78回日本循環器病学会学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Treatments with angiotensin converting enzyme inhibitors and beta blockers for preventing cardiac dysfunction in patients with Duchenne/Becker muscular dystrophy (2013)
  • Author(s): Kimura K, Daimon M, Ebihara A, Kansei U, Takenaka K, Morita H, Nakajima T, Motoyoshi Y, Komori T, Komuro I
  • Organizer: European Society of Cardiology Congress 2013
  • Place of Presentation: Amsterdam, Holland
• [Presentation] A Diagnostic Algorithm to Exclude Elevated Right Atrial Pressure Using Echocardiographic Measurements of Inferior Vena Cava (2013)
  • Author(s): Lee S, Daimon M, Kimura K, Hatano M, Inaba T, Kohro T, Iimuro S, Mizuno Y, Maki H, Koide D, Yao A, Kinugawa K, Yamazaki Y, Komuro I.
  • Organizer: American Heart Association Scientific sessions 2012
  • Place of Presentation: Dallas, U.S.A
• [Presentation] Influencing Factor on Cardiac Structure and Function in Patients with Type 2 Diabetes Mellitus in a Japanese population (2013)
  • Author(s): Ichikawa R, Daimon M, Maruyama M, Miyazaki S, Kawata T, Suzuki H, Ito C, Sato F, Watada H, Daida H
  • Organizer: Japanese Circulation Society
  • Place of Presentation: 横浜
• [Presentation] Surgical Indication for Valvular Heart Disease: An update. (2013)
  • Author(s): Masao Daimon
  • Organizer: Japanese Circulation Society
  • Place of Presentation: 横浜
  • Invited
• [Presentation] A Novel Global Strain Imaging Diastolic Index for the Estimation of Left Ventricular Filling Pressure. (2012)
  • Author(s): Chiang SJ, Daimon M, Ishii K, Hirose K, Kawata T, Miyauchi K, Yah MH, Chang NC, Daida H,
  • Organizer: American Heart Association 2012
  • Place of Presentation: Los Angeles, U.S.A,
• [Presentation] Assessment of Rapid Change of Left Ventricular Filling Pressure Using a Novel Global Strain Imaging Diastolic Index (2012)
  • Author(s): Chiang SJ, Daimon M, Ishii K, Hirose K, Kawata T, Miyauchi K, Yah MH, Chang NC, Daida H
  • Organizer: American Heart Association 2012
  • Place of Presentation: Los Angeles, U.S.A,
• [Presentation] Determinant Factors of Elevated Plasma B-type Natriuretic Peptide Level in Severe Aortic Stenosis (2012)
  • Author(s): Daimon M, Kawata T, Miyazaki S, Ichikawa R, Hirose K, Maruyama M, Suzuki H, Makinae H, Chiang SJ, Miyauchi K, Daida H.
  • Organizer: American Heart Association 2012
  • Place of Presentation: Los Angeles, U.S.A,
• [Presentation] 心不全を心エコー図で診る
  • Author(s): 大門 雅夫
  • Organizer: 日本心臓病学会第45回教育セミナ－
  • Place of Presentation: 大阪
  • Invited
• [Remarks] 東京大学医学部附属病院循環器内科ホームページ 心エコー研究
  • URL: http://plaza.umin.ac.jp/~utok-card/clinical/echocardiography/study
• [Remarks] 東京大学医学部附属病院循環器内科 心エコーチームホームページ
  • URL: http://plaza.umin.ac.jp/~utok-card/clinical/echocardiography