| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this study, we aimed to determine whether global strain imaging diastolic index (SIDI) obtained using 2D speckle tracking imaging (2DSI) could be useful for assessing left ventricular (LV) diastolic function. We found that SIDI showed a stronger correlation with NT-pro BNP levels than conventional diastolic indices in hypertensive patients, and that longitudinal SIDI could predict elevated levels and rapid change of LV filling pressure in the clinical settings. Moreover, we reported that SIDI was useful for detecting coronary artery stenosis without a stress test in patients with normal LV wall motion. 2DSI was also useful for predicting the effect of resynchronizing therapy in congestive heart failure, and for assessing right ventricular (RV) function in rat models with pulmonary hypertension. SIDI derived from 2DSI might be one of promising index for assessing LV and RV function compared with conventional parameters.
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