• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Subvalvular Papillary Muscles Displacement/Dysfunction in Patients with Late Systolic Mitral Valve Prolapse

Research Project

Project/Area Number 24500562
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OTSUJI Yutaka  産業医科大学, 医学部, 教授 (30264427)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Masaaki  産業医科大学, 医学部, 准教授 (30236434)
YOSHITANI Hidetoshi  産業医科大学, 医学部, 助教 (30351894)
HARUKI Nobuhiko  産業医科大学, 医学部, 助教 (70469394)
KUWAKI Hiroshi  産業医科大学, 医学部, 修練指導医 (80623868)
FUKUDA Shota  産業医科大学, 医学部, 助教 (00464610)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsmitral valve / papillary muscle / echocardiography / mitral valve prolapse / 心エコー図 / 僧帽弁逸脱
Outline of Final Research Achievements

Background: We hypothesized that impaired subvalvular geometric stability with papillary muscles (PMs) displacement and/or dysfunction is associated with late-systolic mitral valve prolapse (MVP).
Methods and results:In 15 controls, 10 patients with holo-systolic MVP, and 14 with late-systolic MVP, 1) distances between papillary muscles (PMs) base, PMs tip, and MV annulus and 2) MV coaptation height from its annulus were measured by echocardiography speckle tracking analysis. By multivariate analysis, systolic shift of MV coaptation toward LA was significantly correlated with systolic shift of PMs tip toward LA (r=0.80, p<0.0001), and systolic shift of PMs tip was significantly correlated with both systolic shift of PMs base toward LA (r=0.69, p<0.0001) and reduced PMs contraction(r=0.52, p=0.0007).
Conclusion:Late systolic MVP was associated with impaired stability in subvalvular geometry, including systolic shift of PMs toward LA and impaired PMs contraction.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] The unsaddled annulus biomechanical culprit in mitral vavle prolapse.2013

    • Author(s)
      Morten OJ, Hagege AA, Otsuji Y, Levine RA.
    • Journal Title

      Circulation

      Volume: 127 Pages: 766-768

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Echocardiography is an Adventure of Looking and Thinking2015

    • Author(s)
      尾辻 豊
    • Organizer
      第26回日本心エコー図学会学術集会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Insufficient Papillary Muscle Contraction is Involved in Late Systolic Mitral Valve Prolapse: Quantitative Echocardiographic Study with Speckle Tracking Analysis2012

    • Author(s)
      桑木 恒、竹内正明、JY Jang、BJ Sun,岩瀧麻衣、大谷恭子、舩津順子、春木伸彦、芳谷英俊、JK Song,RA Levine、尾辻 豊
    • Organizer
      American Heart Association 2012
    • Place of Presentation
      Down Town Convention Center(Los Angeles, USA)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi