The effect of local heating to the exercising muscle in interleukin-6 release from the muscle.

Research Project

Project/Area Number	24500605
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Rehabilitation science/Welfare engineering
Research Institution	Kyoto Prefectural University of Medicine (2015) Wakayama Medical University (2012-2014)
Principal Investigator	ITO TOMOYUKI 京都府立医科大学, 医学(系)研究科(研究院), 助教 (90305566)
Co-Investigator(Kenkyū-buntansha)	YOSHIDA TAKAKI 関西医療大学, 保健医療学部, 講師 (60454659)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	インターロイキン６ / 局所温熱 / 運動 / ノルアドレナリン / 体温 / 局所温熱負荷 / トレーニング / TNFーα / 運動負荷 / リハビリテーション
Outline of Final Research Achievements	We examined plasma interleukin-6 (IL-6) response during and after exercise with local heating to contracted skeletal muscle in seven healthy subjects. IL-6 response to local heating in exercise without heating (EX condition), exercise with local heating (HEX condition), and resting with local heating (H condition) were measured. Subject exercised at 60% of VO2max for 30min in EX and HEX, 30min of resting in H condition. Simultaneously, both thigh was warmed by the electric pads for 30 min in HEX and H. Plasma IL-6 increased in HEX after exercise. Local heating without exercise also increased IL-6 2 hours after heating. The examination made it clear that plasma IL-6 response is up-regulated by local heating to skeletal muscle during exercise. We also examined the effect of 10 weeks exercise training with local heating to response of IL-6 during exercise in 4 subjects. Response of IL-6 during exercise with local heating to exercising muscle did not change after training.