| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It found that satiety by diet lowers the swallowing function. The advantage of this was to create a swallowing delay model which can perform in a healthy person. Swallowing suppression by the satiety rather than due to the rise of the blood sugar was revealed to be caused by stretching of the stomach. Stimulation of black pepper with improvement in swallowing function decline elderly patients were also effective in this model. In anaesthetized rats, it was investigated central mechanisms of swallowing suppression by satiety. Microinjection of glucagon like peptide-1(GLP-1) into the dorsal vagal complex (DVC) inhibited swallowing induced by central stimulation of the superior larygeal nerve. The inhibitory reponse was attenuated by treating exendin (5-39), a GLP-1 receptor antagonist, and by electrical lesion of medial NTS, but not commissural part of the NTS and the area postrema. These results suggest that GLP-1 inhibits reflex swallowing via medial NTS in the dorsal medulla.
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