Effect of rehabilitation on the plasticity of cortico-spinal tract after the spinal cord injury
| Project/Area Number |
24500634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | National Hospital Organization Murayama Medical Center |
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Principal Investigator |
Uemura Osamu 独立行政法人国立病院機構村山医療センター(臨床研究部), その他部局等, その他 (90365396)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Kotaro 藤田保健衛生大学, 藤田記念七栗研究所, 准教授 (50618733)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脊髄損傷 / 可塑性 / リハビリテーション / 皮質脊髄路 / 光遺伝学 / トランスジェニック / チャネルロドプシン |
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| Outline of Final Research Achievements |
To reveal the plastic changes of the cortico-spinal tract induced by rehabilitation after the spinal cord injury and to enhance the recovery with external stimulation, we attempted to generate transgenic rats that express channelrhodopsin-GFP fusion protein specifically in the cortico-spinal tract.
We have successfully obtained one transgenic-positive founder. We are currently examining the expression of the transgene.
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Report
(5 results)
Research Products
(17 results)
