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Production of oxidized LDL during exercise in persons with spinal cord injury

Research Project

Project/Area Number 24500748
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionWakayama Medical University

Principal Investigator

MITSUI Toshihito  和歌山県立医科大学, みらい医療推進センター, 助教 (70564186)

Co-Investigator(Kenkyū-buntansha) TAJIMA Fumihiro  和歌山県立医科大学, 医学部, 教授 (00227076)
NAKAMURA Ken  和歌山県立医科大学, 医学部, 准教授 (80299635)
ITO Tomoyuki  和歌山県立医科大学, みらい医療推進センター, 講師 (90305566)
MABUCHI Hiroyuki  和歌山県立医科大学, みらい医療推進センター, 研究員 (50365508)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords障害者スポーツ / 酸化LDL / 脊髄損傷 / 車いすマラソン / 障がい者スポーツ / アドレナリン / 抗酸化 / 運動負荷
Outline of Final Research Achievements

In persons with cervical spinal cord injury (CSCI), adrenalin secretion during exercise is absent due to a loss of sympathetic nervous control for adrenal medulla, while it’s intact in persons with lumbar spinal cord injury (LSCI). We hypothesized that a loss of adrenalin secretion during exercise would be associated with a production of oxidized LDL. Now we observed that both of oxidized LDL and plasma adrenaline did not increase in CSCI, while both increased in LSCI. The present results suggest that no increase in oxidized LDL for CSCI is associated with the loss of adrenalin secretion and that CSCI can exercise safely until at the exercise intensity set up in the present study.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 頸髄損傷者における酸化LDLの動態について2016

    • Author(s)
      三井利仁
    • Organizer
      日本障がい者スポーツ学会
    • Place of Presentation
      新潟県障がい者交流センター
    • Year and Date
      2016-03-26 – 2016-03-27
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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