The ACTN3 gene is a potential biomarker for the risk of non-contact sports injury in female athletes
| Project/Area Number |
24500775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
MASUMI Kyoko 武庫川女子大学, 薬学部, 助手 (70379593)
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| Co-Investigator(Renkei-kenkyūsha) |
KINOSHITA Kenji 武庫川女子大学, 薬学部, 教授 (70441219)
MURATA Shigenori 武庫川女子大学, 薬学部, 准教授 (80280999)
HAYASHIDA Mariko 武庫川女子大学, 薬学部, 助手 (10611387)
KOYANAGI Yoshio 武庫川女子大学, 健康スポーツ科学部, 准教授 (20340945)
NAKATA Ken 大阪大学, 医学系研究科, 教授 (00283747)
YONETANI Yasukazu 大阪大学, 医学系研究科, 助教 (80642090)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | スポーツ科学 / トレーニング科学 / 遺伝子解析 |
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| Outline of Final Research Achievements |
Sports injuries can become serious impairments for all athletes. Most notably, female athletes are at higher risk than men for sports injury, for example, anterior cruciate ligament (ACL) disorder. However, there is currently no genetic marker to determine if a female athlete harbors a predisposition for muscle trauma. Hence, we performed single nucleotide polymorphism genotyping of the α-actinin-3 (ACTN3) in 99 young female athletes who had been injured during a sports activity, and we compared the occurrence of muscle traumas with the genotypes using the chi-square test. For the ACTN3 577R allele, the subjects who had non-contact muscle injury had a marked increase in frequency (p-value = 0.0015; odds ratio = 2.52). The significant increase in non-contact muscle injury related to ACTN3 577R alleles suggests that ACTN3 is likely to be involved in muscle strain and that non-contact muscle injury might occur due to the presence of this allele.
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Report
(4 results)
Research Products
(4 results)
